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Tclin
NDUFS5
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This gene is a member of the NADH dehydrogenase (ubiquinone) iron-sulfur protein family. The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 1, 4 and 17. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372967
  • ENSP00000362058
  • ENSG00000168653
  • ENST00000372969
  • ENSP00000362060

Symbol
  • CI15K
  • CI-15k
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
small molecule perturbation
0.81
virus perturbation
0.76
transcription factor binding site profile
0.65
co-expressed gene
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.25   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.25   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
5.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
5.6
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit S5
VGNC:8079
456776
Macaque
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
693506
Macaque
NADH:ubiquinone oxidoreductase subunit S5
718553
Mouse
MGI:1890889
595136
Rat
RGD:1311081
362588
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit S5
Macaque
NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Macaque
NADH:ubiquinone oxidoreductase subunit S5
Mouse
Rat
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43920-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (203)
1 – 10 of 203
NDUFA12
Tclin
Family: Enzyme
Novelty: 0.04679316
p_int: 0.999717458
p_ni: 0.000282542
Score: 0.999
Data Source: BioPlex,STRINGDB
CAPNS2
Tbio
Novelty: 0.45658116
p_int: 0.999654487
p_ni: 0.00028432
p_wrong: 0.000061193
Data Source: BioPlex
NDUFS4
Tclin
Family: Enzyme
Novelty: 0.00787292
p_int: 0.999468803
p_ni: 0.00052984
p_wrong: 0.000001356
Score: 0.999
Data Source: BioPlex,STRINGDB
SDR9C7
Tbio
Family: Enzyme
Novelty: 0.01618496
p_int: 0.9992074
p_ni: 0.0007926
Data Source: BioPlex
ECSIT
Tbio
Novelty: 0.04690184
p_int: 0.998784347
p_ni: 0.001215653
Score: 0.958
Data Source: BioPlex,STRINGDB
NDUFB7
Tclin
Family: Enzyme
Novelty: 0.14580093
p_int: 0.998662714
p_ni: 0.001332953
p_wrong: 0.000004333
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFC2
Tclin
Family: Enzyme
Novelty: 0.08387385
p_int: 0.998559077
p_ni: 0.001440923
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB9
Tclin
Family: Enzyme
Novelty: 0.00715628
p_int: 0.998336167
p_ni: 0.001663476
p_wrong: 3.57e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB5
Tclin
Family: Enzyme
Novelty: 0.0257403
p_int: 0.997397644
p_ni: 0.002602322
p_wrong: 3.5e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB1
Tclin
Family: Enzyme
Novelty: 0.08981517
p_int: 0.996532606
p_ni: 0.000335357
p_wrong: 0.003132037
Score: 0.998
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  6.25

PubMed score by year
PubTator Score  2.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer