Tclin NDUFS5 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5

Protein Summary

Description

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This gene is a member of the NADH dehydrogenase (ubiquinone) iron-sulfur protein family. The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants and pseudogenes have been identified on chromosomes 1, 4 and 17. [provided by RefSeq, May 2010]

Uniprot Accession IDs

• O43920

Gene Name

• NDUFS5

Ensembl ID

• ENST00000372967
• ENSP00000362058
• ENSG00000168653
• ENST00000372969
• ENSP00000362060

Symbol

• CI15K
• CI-15k

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.87
small molecule perturbation	0.81
virus perturbation	0.76
transcription factor binding site profile	0.65
co-expressed gene	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.33   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 197   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.33   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

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1 – 1 of 1

metformin

NDUFS5Tclin Enzyme

INHIBITOR :

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (203)

Explore Interacting Targets

1 – 10 of 203

• See Interactions on String-DB

NDUFA12

Tclin

Family:  Enzyme

Novelty:  0.04679316

p_int:  0.999717458

p_ni:  0.000282542

Score:  0.999

Data Source:  BioPlex,STRINGDB

CAPNS2

Tbio

Novelty:  0.45658116

p_int:  0.999654487

p_ni:  0.00028432

p_wrong:  0.000061193

Data Source:  BioPlex

NDUFS4

Tclin

Family:  Enzyme

Novelty:  0.00787292

p_int:  0.999468803

p_ni:  0.00052984

p_wrong:  0.000001356

Score:  0.999

Data Source:  BioPlex,STRINGDB

SDR9C7

Tbio

Family:  Enzyme

Novelty:  0.01618496

p_int:  0.9992074

p_ni:  0.0007926

Data Source:  BioPlex

ECSIT

Tbio

Novelty:  0.04690184

p_int:  0.998784347

p_ni:  0.001215653

Score:  0.958

Data Source:  BioPlex,STRINGDB

NDUFB7

Tclin

Family:  Enzyme

Novelty:  0.14580093

p_int:  0.998662714

p_ni:  0.001332953

p_wrong:  0.000004333

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFC2

Tclin

Family:  Enzyme

Novelty:  0.08387385

p_int:  0.998559077

p_ni:  0.001440923

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFB9

Tclin

Family:  Enzyme

Novelty:  0.00715628

p_int:  0.998336167

p_ni:  0.001663476

p_wrong:  3.57e-7

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFB5

Tclin

Family:  Enzyme

Novelty:  0.0257403

p_int:  0.997397644

p_ni:  0.002602322

p_wrong:  3.5e-8

Score:  0.999

Data Source:  BioPlex,STRINGDB

NDUFB1

Tclin

Family:  Enzyme

Novelty:  0.08981517

p_int:  0.996532606

p_ni:  0.000335357

p_wrong:  0.003132037

Score:  0.998

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (17)

Reactome (5)

KEGG (8)

WikiPathways (4)

Complex I biogenesis (R-HSA-6799198)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Complex I biogenesis	55 targets	R-HSA-6799198
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Respiratory electron transport	101 targets	R-HSA-611105
Reactome	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200
Reactome	The citric acid (TCA) cycle and respiratory electron transport	174 targets	R-HSA-1428517

Name	Explore in Pharos	Explore in Source
Complex I biogenesis	55 targets	R-HSA-6799198
Metabolism	2112 targets	R-HSA-1430728
Respiratory electron transport	101 targets	R-HSA-611105
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	123 targets	R-HSA-163200
The citric acid (TCA) cycle and respiratory electron transport	174 targets	R-HSA-1428517

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Functions (1)

Components (4)

Processes (2)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
NADH dehydrogenase (ubiquinone) activity	Non-traceable Author Statement (NAS)	UniProtKB

Disease Associations (null)

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	3	2	4		82
body mass index	EFO_0004340	2	1	2		66.3
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		42.1
Headache	HP_0002315	1	1	1		36.3
migraine disorder	MONDO_0005277	1	1	0	1	33.1

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
high density lipoprotein cholesterol measurement	EFO_0004612	4		82
body mass index	EFO_0004340	2		66.3
apolipoprotein A 1 measurement	EFO_0004614	1		42.1
Headache	HP_0002315	1		36.3
migraine disorder	MONDO_0005277	0	1	33.1

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Disulfide bond
Electron transport
Membrane
Mitochondrion
Mitochondrion inner membrane
Polymorphism
Reference proteome
Respiratory chain

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
body mass index
C-reactive protein measurement
Headache
high density lipoprotein cholesterol measurement
lymphocyte count
migraine disorder
phosphatidylcholine measurement
testosterone measurement

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	NADH:ubiquinone oxidoreductase subunit S5	VGNC:8079	456776
Macaque	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5		693506
Macaque	NADH:ubiquinone oxidoreductase subunit S5		718553
Mouse	NADH:ubiquinone oxidoreductase core subunit S5	MGI:1890889	595136
Rat	NADH:ubiquinone oxidoreductase subunit S5	RGD:1311081	362588

Species	Name	OMA	EggNOG	Inparanoid
Chimp	NADH:ubiquinone oxidoreductase subunit S5
Macaque	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Macaque	NADH:ubiquinone oxidoreductase subunit S5
Mouse	NADH:ubiquinone oxidoreductase core subunit S5
Rat	NADH:ubiquinone oxidoreductase subunit S5

Publication Statistics

PubMed Score 8.33

PubMed score by year

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PubTator Score 2.42

PubTator score by year

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Related Publications

Text Mined References (20)

GeneRif Annotations (2)

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10

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PMID	Year	Title