Tbio CHST1 Carbohydrate sulfotransferase 1

Protein Summary

Description

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the sulfation of the proteoglycan keratin. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• O43916
• D3DQP2

Gene Name

• CHST1

Ensembl ID

• ENST00000308064
• ENSP00000309270
• ENSG00000175264

Symbol

• C6ST
• KSST
• GST-1
• KS6ST
• KSGal6ST

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.74
gene perturbation	0.68
tissue sample	0.63
pathway	0.58
tissue	0.57

Protein Classes

DTO Classes

Carbohydrate Sulfotransferase 12 / Carbohydrate Sulfotransferase 14 / Carbohydrate Sulfotransferase 13 / Carbohydrate Sulfotransferase 10 / Carbohydrate Sulfotransferase 11

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.33   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 196   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.33   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0