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Tbio
CHST1
Carbohydrate sulfotransferase 1

Protein Summary
Description
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of galactose (Gal) residues of keratan. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer. The sulfotransferase activity on sialyl LacNAc structures is much higher than the corresponding desialylated substrate, and only internal Gal residues are sulfated. May function in the sulfation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins. Participates in biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. This locus encodes a member of the keratin sulfotransferase family of proteins. The encoded enzyme catalyzes the sulfation of the proteoglycan keratin. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308064
  • ENSP00000309270
  • ENSG00000175264

Symbol
  • C6ST
  • KSST
  • GST-1
  • KS6ST
  • KSGal6ST
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.74
gene perturbation
0.68
tissue sample
0.63
pathway
0.58
tissue
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.86   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.86   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
LUM
Tbio
Novelty:  0.00219939
Score:  0.974
Data Source:  STRINGDB
KERA
Tbio
Novelty:  0.00789599
Score:  0.973
Data Source:  STRINGDB
ACAN
Tbio
Novelty:  0.00033695
Score:  0.905
Data Source:  STRINGDB
FMOD
Tbio
Novelty:  0.00459438
Score:  0.902
Data Source:  STRINGDB
OGN
Tbio
Novelty:  0.00097407
Score:  0.902
Data Source:  STRINGDB
OMD
Tbio
Novelty:  0.01992089
Score:  0.9
Data Source:  STRINGDB
PRELP
Tbio
Novelty:  0.02849334
Score:  0.9
Data Source:  STRINGDB
CHST9
Tbio
Family:  Enzyme
Novelty:  0.21203005
Score:  0.661
Data Source:  STRINGDB
NTAN1
Tbio
Family:  Enzyme
Novelty:  0.01112132
Score:  0.642
Data Source:  STRINGDB
GLCE
Tbio
Family:  Enzyme
Novelty:  0.0497423
Score:  0.625
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Glycosaminoglycan metabolism (R-HSA-1630316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycosaminoglycan metabolism
Reactome
Keratan sulfate biosynthesis
Reactome
Keratan sulfate/keratin metabolism
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
Glycosaminoglycan metabolism
Keratan sulfate biosynthesis
Keratan sulfate/keratin metabolism
Metabolism
Metabolism of carbohydrates
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
1
1
0
5.8
6
peak insulin response measurement
1
1
1
2.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
0
5.8
6
peak insulin response measurement
1
2.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
carbohydrate sulfotransferase 1
VGNC:8155
466500
Macaque
carbohydrate sulfotransferase 1
715176
Mouse
MGI:1924219
76969
Rat
RGD:1308142
295934
Dog
carbohydrate sulfotransferase 1
VGNC:39249
483642
Species
Name
OMA
EggNOG
Inparanoid
Chimp
carbohydrate sulfotransferase 1
Macaque
carbohydrate sulfotransferase 1
Mouse
Rat
Dog
carbohydrate sulfotransferase 1
Publication Statistics
PubMed Score 19.86
PubMed score by year
PubTator Score 9.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title