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Tbio
TYROBP
TYRO protein tyrosine kinase-binding protein

Protein Summary
Description
Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin. This gene encodes a transmembrane signaling polypeptide which contains an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic domain. The encoded protein may associate with the killer-cell inhibitory receptor (KIR) family of membrane glycoproteins and may act as an activating signal transduction element. This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a role in signal transduction, bone modeling, brain myelination, and inflammation. Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. Its putative receptor, triggering receptor expressed on myeloid cells 2 (TREM2), ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262629
  • ENSP00000262629
  • ENSG00000011600
  • ENST00000544690
  • ENSP00000445332
  • ENST00000589517
  • ENSP00000468447

Symbol
  • DAP12
  • KARAP
  • DAP12
  • KARAP
  • PLOSL
  • PLOSL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
tissue sample
0.71
disease perturbation
0.68
co-expressed gene
0.65
tissue
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.38   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 253.38   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.9
78.5
creatinine measurement
1
1
1
66.8
thrombomodulin measurement
1
1
1
64
glomerular filtration rate
1
1
1
62.8
vitamin D measurement
2
1
2
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
78.5
creatinine measurement
1
66.8
thrombomodulin measurement
1
64
glomerular filtration rate
1
62.8
vitamin D measurement
2
53.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TYRO protein tyrosine kinase binding protein
VGNC:2209
455968
Macaque
TYRO protein tyrosine kinase binding protein
574207
Mouse
MGI:1277211
22177
Rat
RGD:1303081
361537
Dog
TYRO protein tyrosine kinase binding protein
VGNC:48028
476477
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TYRO protein tyrosine kinase binding protein
Macaque
TYRO protein tyrosine kinase binding protein
Mouse
Rat
Dog
TYRO protein tyrosine kinase binding protein
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43914-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (19)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Cell-Cell communication
Reactome
DAP12 interactions
Reactome
DAP12 signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Cell-Cell communication
DAP12 interactions
DAP12 signaling
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (397)
1 – 10 of 397
SMAD5
Tbio
Family:  TF
Novelty:  0.00405952
p_int:  0.99996282
p_ni:  0.000026625
p_wrong:  0.000010555
Data Source:  BioPlex
MTHFR
Tbio
Family:  Enzyme
Novelty:  0.00018162
p_int:  0.999792974
p_ni:  0.000207025
Data Source:  BioPlex
SLC35B2
Tbio
Family:  Transporter
Novelty:  0.01516638
p_int:  0.998738888
p_ni:  0.001261062
p_wrong:  5e-8
Data Source:  BioPlex
GBF1
Tbio
Novelty:  0.10901631
p_int:  0.998348475
p_ni:  0.001651525
Data Source:  BioPlex
EXTL2
Tbio
Family:  Enzyme
Novelty:  0.05051027
p_int:  0.994007716
p_ni:  0.003139563
p_wrong:  0.002852721
Data Source:  BioPlex
DNM2
Tchem
Novelty:  0.00265965
p_int:  0.990984016
p_ni:  0.009015984
Data Source:  BioPlex
DNM3
Tbio
Novelty:  0.02365643
p_int:  0.98549997
p_ni:  0.01450003
Data Source:  BioPlex
TMX4
Tdark
Novelty:  0.2628295
p_int:  0.984847467
p_ni:  0.015152532
p_wrong:  1e-9
Data Source:  BioPlex
RETREG3
Tdark
Novelty:  0.99215801
p_int:  0.952524353
p_ni:  0.047475647
Data Source:  BioPlex
GPIHBP1
Tbio
Novelty:  0.01241227
p_int:  0.947512872
p_ni:  0.00404445
p_wrong:  0.048442677
Data Source:  BioPlex
Publication Statistics
PubMed Score  253.38

PubMed score by year
PubTator Score  130

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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