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Tbio
ORC5
Origin recognition complex subunit 5

Protein Summary
Description
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297431
  • ENSP00000297431
  • ENSG00000164815
  • ENST00000447452
  • ENSP00000395747

Symbol
  • ORC5L
  • ORC5L
  • ORC5P
  • ORC5T
  • PPP1R117
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.86
disease perturbation
0.83
histone modification site profile
0.78
transcription factor binding site profile
0.75
tissue sample
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.47   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.47   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (147)
1 – 10 of 147
DPEP1
Tclin
Family:  Enzyme
Novelty:  0.00384946
p_int:  0.999994922
p_ni:  0.000005078
Data Source:  BioPlex
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
p_int:  0.999930718
p_ni:  0.000069278
p_wrong:  4e-9
Data Source:  BioPlex
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.999310464
p_ni:  0.000689534
p_wrong:  1e-9
Data Source:  BioPlex
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.999042434
p_ni:  0.00094972
p_wrong:  0.000007846
Data Source:  BioPlex
APLNR
Tchem
Family:  GPCR
Novelty:  0.00224203
p_int:  0.998716289
p_ni:  0.001283698
p_wrong:  1.3e-8
Data Source:  BioPlex
LYPD3
Tbio
Novelty:  0.03248533
p_int:  0.997641756
p_ni:  0.000998043
p_wrong:  0.0013602
Data Source:  BioPlex
FAM234B
Tdark
Novelty:  1.53957047
p_int:  0.996585675
p_ni:  0.003136246
p_wrong:  0.00027808
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.99422783
p_ni:  0.005769817
p_wrong:  0.000002353
Data Source:  BioPlex
C3AR1
Tchem
Family:  GPCR
Novelty:  0.00527301
p_int:  0.992817923
p_ni:  0.007135645
p_wrong:  0.000046432
Data Source:  BioPlex
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.988719915
p_ni:  0.011273385
p_wrong:  0.0000067
Data Source:  BioPlex
Pathways (24)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Activation of the pre-replicative complex
Reactome
Assembly of the ORC complex at the origin of replication
Reactome
Assembly of the pre-replicative complex
Reactome
CDC6 association with the ORC:origin complex
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Activation of the pre-replicative complex
Assembly of the ORC complex at the origin of replication
Assembly of the pre-replicative complex
CDC6 association with the ORC:origin complex
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
5
3
5
60.9
alcohol use disorder measurement
1
1
1
46.5
bitter alcoholic beverage consumption measurement
1
1
1
3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
5
60.9
alcohol use disorder measurement
1
46.5
bitter alcoholic beverage consumption measurement
1
3
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
origin recognition complex subunit 5
VGNC:4454
463636
Macaque
origin recognition complex subunit 5
696683
Mouse
MGI:1347044
26429
Rat
RGD:1561088
362304
Dog
origin recognition complex subunit 5
VGNC:44144
609937
Species
Name
OMA
EggNOG
Inparanoid
Chimp
origin recognition complex subunit 5
Macaque
origin recognition complex subunit 5
Mouse
Rat
Dog
origin recognition complex subunit 5
Publication Statistics
PubMed Score 41.47
PubMed score by year
PubTator Score 11.26
PubTator score by year