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Tbio
EXTL3
Exostosin-like 3

Protein Summary
Description
Glycosyltransferase which regulates the biosynthesis of heparan sulfate (HS). Important for both skeletal development and hematopoiesis, through the formation of HS proteoglycans (HSPGs) (PubMed:28132690, PubMed:28148688). Required for the function of REG3A in regulating keratinocyte proliferation and differentiation (PubMed:22727489). This gene encodes a single-pass membrane protein which functions as a glycosyltransferase. The encoded protein catalyzes the transfer of N-acetylglucosamine to glycosaminoglycan chains. This reaction is important in heparin and heparan sulfate synthesis. Alternative splicing results in the multiple transcript variants. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220562
  • ENSP00000220562
  • ENSG00000012232

Symbol
  • EXTL1L
  • EXTR1
  • KIAA0519
  • RPR
  • BOTV
  • REGR
  • EXTR1
  • ISDNA
  • EXTL1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
disease perturbation
0.9
virus perturbation
0.79
biological process
0.71
histone modification site profile
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.79   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.79   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.997917426
p_ni:  0.002082574
Data Source:  BioPlex
DEFA6
Tbio
Novelty:  0.0363171
p_int:  0.996021286
p_ni:  0.003978714
Data Source:  BioPlex
SCARA3
Tbio
Novelty:  0.00621523
p_int:  0.995155337
p_ni:  0.004844663
Data Source:  BioPlex
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.988845581
p_ni:  0.011154419
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.967585207
p_ni:  0.032414792
Data Source:  BioPlex
ADCY9
Tbio
Family:  Enzyme
Novelty:  0.00744116
p_int:  0.966974984
p_ni:  0.033025016
Data Source:  BioPlex
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.952948306
p_ni:  0.047051694
Data Source:  BioPlex
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.925758629
p_ni:  0.074241371
Data Source:  BioPlex
WBP1
Tbio
Novelty:  1.24967974
p_int:  0.910942431
p_ni:  0.089057566
p_wrong:  3e-9
Data Source:  BioPlex
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.895033416
p_ni:  0.104966584
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Reactome
XBP1(S) activates chaperone genes
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Metabolism of proteins
Unfolded Protein Response (UPR)
XBP1(S) activates chaperone genes
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
38.8
body height
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
38.8
body height
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
exostosin like glycosyltransferase 3
VGNC:12004
464086
Macaque
exostosin like glycosyltransferase 3
100426593
Mouse
MGI:1860765
54616
Rat
RGD:62065
56819
Dog
exostosin like glycosyltransferase 3
VGNC:40535
486091
Species
Name
OMA
EggNOG
Inparanoid
Chimp
exostosin like glycosyltransferase 3
Macaque
exostosin like glycosyltransferase 3
Mouse
Rat
Dog
exostosin like glycosyltransferase 3
Publication Statistics
PubMed Score 138.79
PubMed score by year
PubTator Score 33.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title