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Tbio
GAS2
Growth arrest-specific protein 2

Protein Summary
Description
May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity). The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278187
  • ENSP00000278187
  • ENSG00000148935
  • ENST00000454584
  • ENSP00000401145
  • ENST00000524701
  • ENSP00000432026
  • ENST00000630668
  • ENSP00000485708

Symbol
  • GAS-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.94
trait
0.86
transcription factor
0.65
PubMedID
0.64
transcription factor perturbation
0.61


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.15   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 282   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.15   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 282   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth arrest specific 2
VGNC:3271
451081
Macaque
growth arrest specific 2
700952
Mouse
MGI:95657
14453
Rat
RGD:1563167
499156
Dog
growth arrest specific 2
VGNC:41115
476889
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth arrest specific 2
Macaque
growth arrest specific 2
Mouse
Rat
Dog
growth arrest specific 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43903-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Caspase-mediated cleavage of cytoskeletal proteins
Reactome
Programmed Cell Death
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Caspase-mediated cleavage of cytoskeletal proteins
Programmed Cell Death
Gene Ontology Terms (12)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (45)
1 – 10 of 45
GAS1
Tbio
Novelty:  0.00423304
Score:  0.932
Data Source:  STRINGDB
CASP3
Tchem
Family:  Enzyme
Novelty:  0.00003555
Score:  0.918
Data Source:  Reactome,STRINGDB
CASP7
Tchem
Family:  Enzyme
Novelty:  0.00126224
Score:  0.912
Data Source:  Reactome,STRINGDB
LUZP2
Tdark
Novelty:  0.34485558
Score:  0.904
Data Source:  STRINGDB
RASL10A
Tbio
Family:  Enzyme
Novelty:  0.1724649
Score:  0.757
Data Source:  STRINGDB
LIPI
Tbio
Family:  Enzyme
Novelty:  0.00512911
Score:  0.743
Data Source:  STRINGDB
SPA17
Tbio
Novelty:  0.02632554
Score:  0.711
Data Source:  STRINGDB
CAPN2
Tchem
Novelty:  0.00431673
Score:  0.647
Data Source:  STRINGDB
PMP22
Tbio
Novelty:  0.00256307
Score:  0.642
Data Source:  STRINGDB
SUPT16H
Tbio
Family:  Enzyme
Novelty:  0.01026868
Score:  0.638
Data Source:  STRINGDB
Publication Statistics
PubMed Score  71.15

PubMed score by year
PubTator Score  27.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer