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Tbio
CREB3
Cyclic AMP-responsive element-binding protein 3

Protein Summary
Description
Endoplasmic reticulum (ER)-bound sequence-specific transcription factor that directly binds DNA and activates transcription (PubMed:9271389, PubMed:19779205, PubMed:10984507, PubMed:15845366, PubMed:16940180). Plays a role in the unfolded protein response (UPR), promoting cell survival versus ER stress-induced apoptotic cell death (PubMed:15845366, PubMed:16940180). Also involved in cell proliferation, migration and differentiation, tumor suppression and inflammatory gene expression. Acts as a positive regulator of LKN-1/CCL15-induced chemotaxis signaling of leukocyte cell migration (PubMed:19779205, PubMed:15001559, PubMed:17296613). Associates with chromatin to the HERPUD1 promoter (PubMed:16940180). Also induces transcriptional activation of chemokine receptors (PubMed:18587271, PubMed:17296613). Processed cyclic AMP-responsive element-binding protein 3: This is the transcriptionally active form that translocates to the nucleus and activates unfolded protein response (UPR) target ge ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353704
  • ENSP00000342136
  • ENSG00000107175

Symbol
  • LZIP
  • LZIP
  • LUMAN
  • sLZIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.97
transcription factor binding site profile
0.93
biological process
0.84
virus perturbation
0.83
molecular function
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.97   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 238   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.97   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 238   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (121)
CREB3 factors activate genes (R-HSA-8874211)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
CREB3 factors activate genes
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Name
Explore in Pharos
Explore in Source
CREB3 factors activate genes
Metabolism of proteins
Unfolded Protein Response (UPR)
Gene Ontology Terms (49)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Mutant Phenotype (IMP)
NTNU_SB
Protein-Protein Interactions (114)
1 – 10 of 114
CREB3L2
Tbio
Family: TF
Novelty: 0.0284456
p_int: 0.999999525
p_ni: 3.56e-7
p_wrong: 1.19e-7
Score: 0.895
Data Source: BioPlex,STRINGDB
NPHP3
Tbio
Novelty: 0.02857926
p_int: 0.999980996
p_ni: 0.000019004
Score: 0.183
Data Source: BioPlex,STRINGDB
PDGFC
Tbio
Novelty: 0.00642236
p_int: 0.999962019
p_ni: 0.000019122
p_wrong: 0.000018859
Score: 0.412
Data Source: BioPlex,STRINGDB
TRIM26
Tbio
Novelty: 0.07177119
p_int: 0.999527413
p_ni: 0.000472587
Data Source: BioPlex
UHRF1BP1
Tbio
Novelty: 0.1588079
p_int: 0.997326129
p_ni: 0.002673871
p_wrong: 1e-9
Score: 0.261
Data Source: BioPlex,STRINGDB
RNF41
Tbio
Family: Enzyme
Novelty: 0.01953473
p_int: 0.99519171
p_ni: 0.004807046
p_wrong: 0.000001245
Score: 0.218
Data Source: BioPlex,STRINGDB
HCFC1
Tbio
Novelty: 0.00440762
p_int: 0.992460217
p_ni: 0.007539783
Score: 0.854
Data Source: BioPlex,STRINGDB
HCFC2
Tbio
Novelty: 0.12260416
p_int: 0.992236525
p_ni: 0.007763475
Score: 0.855
Data Source: BioPlex,STRINGDB
OGT
Tchem
Family: Enzyme
Novelty: 0.00290822
p_int: 0.986339533
p_ni: 0.013660467
Score: 0.656
Data Source: BioPlex,STRINGDB
C18orf25
Tdark
Novelty: 0.67505268
p_int: 0.952890251
p_ni: 0.046992155
p_wrong: 0.000117594
Score: 0.183
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  155.97

PubMed score by year
PubTator Score  33.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer