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Tchem
SLC28A2
Sodium/nucleoside cotransporter 2

Protein Summary
Description
Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347644
  • ENSP00000315006
  • ENSG00000137860

Symbol
  • CNT2
  • CNT2
  • HCNT2
  • SPNT1
  • HsT17153
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
protein domain
0.85
phenotype
0.58
PubMedID
0.46
chemical
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.07   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.07   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Reactome
Transport of small molecules
Reactome
Transport of vitamins, nucleosides, and related molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane
Transport of small molecules
Transport of vitamins, nucleosides, and related molecules
Protein-Protein Interactions (38)
1 – 10 of 38
SLC29A2
Tbio
Family: Transporter
Novelty: 0.00801619
Score: 0.869
Data Source: STRINGDB
SLC29A1
Tclin
Family: Transporter
Novelty: 0.002085
Score: 0.869
Data Source: STRINGDB
SLC30A4
Tbio
Family: Transporter
Novelty: 0.02209
Score: 0.749
Data Source: STRINGDB
GATM
Tbio
Family: Enzyme
Novelty: 0.00340356
Score: 0.747
Data Source: STRINGDB
SLC22A1
Tchem
Family: Transporter
Novelty: 0.00427728
Score: 0.72
Data Source: STRINGDB
SLC29A3
Tbio
Family: Transporter
Novelty: 0.01133239
Score: 0.719
Data Source: STRINGDB
DUOX1
Tbio
Family: Enzyme
Novelty: 0.00185195
Score: 0.716
Data Source: STRINGDB
DUOX2
Tchem
Family: Enzyme
Novelty: 0.00221295
Score: 0.71
Data Source: STRINGDB
SLC13A1
Tbio
Family: Transporter
Novelty: 0.01582826
Score: 0.682
Data Source: STRINGDB
SLC29A4
Tchem
Family: Transporter
Novelty: 0.00772914
Score: 0.6
Data Source: STRINGDB
Publication Statistics
PubMed Score  98.07

PubMed score by year
PubTator Score  67.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer