Tbio EDIL3 EGF-like repeat and discoidin I-like domain-containing protein 3

Protein Summary

Description

Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development. The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43854
• B2R763
• O43855
• Q5D094
• Q8N610

Gene Name

• EDIL3

Ensembl ID

• ENST00000296591
• ENSP00000296591
• ENSG00000164176
• ENST00000380138
• ENSP00000369483

Symbol

• DEL1
• DEL1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.99
protein domain	0.97
trait	0.93
gene perturbation	0.8
virus perturbation	0.72

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Membrane-bound Signaling Molecule / Egf-like Repeat And Discoidin I-like Domain-containing Protein 3

Protein / Receptor / Egf-like Repeat And Discoidin I-like Domain-containing Protein 3

Protein / Hydrolase / Egf-like Repeat And Discoidin I-like Domain-containing Protein 3

Protein / Cell Adhesion Molecule / Egf-like Repeat And Discoidin I-like Domain-containing Protein 3

DTO Classes

Protein / Enzyme / Hydrolase / Egf-like Repeat And Discoidin I-like Domain-containing Protein 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.02   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 255   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.02   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0