Protein Classes
Protein Summary
Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
- ENST00000249364
- ENSP00000249364
- ENSG00000128595
- ENST00000449187
- ENSP00000408838
- ENST00000479257
- ENSP00000420381
- ENST00000535011
- ENSP00000442110
- ENST00000542996
- ENSP00000438248
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.99 | ||
disease perturbation | 0.97 | ||
kinase perturbation | 0.93 | ||
microRNA | 0.93 | ||
interacting protein | 0.87 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.52 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 240 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 83.52 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 240 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 3 | 2 | 3 | 98.5 | |||||
mathematical ability | 4 | 2 | 4 | 98.5 | |||||
cognitive function measurement | 3 | 1 | 3 | 95.3 | |||||
intelligence | 2 | 1 | 1 | 6.1 | 76.5 | ||||
alcohol consumption measurement | 1 | 1 | 1 | 47.6 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 3 | 98.5 | |||||
mathematical ability | 4 | 98.5 | |||||
cognitive function measurement | 3 | 95.3 | |||||
intelligence | 1 | 6.1 | 76.5 | ||||
alcohol consumption measurement | 1 | 47.6 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | calumenin | 699730 | ||||||
Mouse | MGI:1097158 | 12321 | ||||||
Rat | RGD:620383 | 64366 | ||||||
Dog | calumenin | VGNC:54755 | 475201 | |||||
Horse | calumenin | 100056849 | ||||||
Pathways (16)
Reactome (8)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Hemostasis | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Platelet activation, signaling and aggregation | ||||
Reactome | Platelet degranulation | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Hemostasis | ||||
Metabolism of proteins | ||||
Platelet activation, signaling and aggregation | ||||
Platelet degranulation | ||||
Post-translational protein modification | ||||
Gene Ontology Terms (11)
Functions (1)
Components (8)
Processes (2)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Protein-Protein Interactions (198)
1 – 10 of 198
IGF2
Novelty: 0.00021277
p_int: 0.999758178
p_ni: 0.000241823
Data Source: BioPlex
MRPS7
Novelty: 0.00153134
p_int: 0.912880822
p_ni: 0.087119178
Score: 0.249
Data Source: BioPlex,STRINGDB
HIC2
Family: TF
Novelty: 0.1544738
p_int: 0.808319625
p_ni: 0.175428987
p_wrong: 0.016251388
Score: 0.282
Data Source: BioPlex,STRINGDB
P4HB
Family: Enzyme
Novelty: 0.00107905
Score: 0.991
Data Source: STRINGDB
HSP90B1
Novelty: 0.00135881
Score: 0.964
Data Source: STRINGDB
PDIA6
Family: Enzyme
Novelty: 0.01692178
Score: 0.947
Data Source: STRINGDB
ALB
Novelty: 0.00000616
Score: 0.945
Data Source: STRINGDB
PCSK9
Family: Enzyme
Novelty: 0.00030553
Score: 0.943
Data Source: STRINGDB
FN1
Novelty: 0.00003647
Score: 0.937
Data Source: STRINGDB
FGA
Novelty: 0.00107227
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score 83.52
PubMed score by year
PubTator Score 42.02
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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