Protein Classes
Protein Summary
Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
- ENST00000249364
- ENSP00000249364
- ENSG00000128595
- ENST00000449187
- ENSP00000408838
- ENST00000479257
- ENSP00000420381
- ENST00000535011
- ENSP00000442110
- ENST00000542996
- ENSP00000438248
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.99 | ||
disease perturbation | 0.97 | ||
kinase perturbation | 0.93 | ||
microRNA | 0.93 | ||
interacting protein | 0.87 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 73.66 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 240 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 73.66 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 240 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (16)
Reactome (8)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Hemostasis | ||||
Reactome | Metabolism of proteins | ||||
Reactome | Platelet activation, signaling and aggregation | ||||
Reactome | Platelet degranulation | ||||
Reactome | Post-translational protein modification | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Hemostasis | ||||
Metabolism of proteins | ||||
Platelet activation, signaling and aggregation | ||||
Platelet degranulation | ||||
Post-translational protein modification | ||||
Gene Ontology Terms (11)
Functions (1)
Components (8)
Processes (2)
Items per page:
10
1 – 1 of 1
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Protein-Protein Interactions (198)
1 – 10 of 198
IGF2
Novelty: 0.00024884
p_int: 0.999758178
p_ni: 0.000241823
Data Source: BioPlex
MRPS7
Novelty: 0.00146168
p_int: 0.912880822
p_ni: 0.087119178
Score: 0.249
Data Source: BioPlex,STRINGDB
HIC2
Family: TF
Novelty: 0.39202376
p_int: 0.808319625
p_ni: 0.175428987
p_wrong: 0.016251388
Score: 0.282
Data Source: BioPlex,STRINGDB
P4HB
Family: Enzyme
Novelty: 0.00117072
Score: 0.991
Data Source: STRINGDB
HSP90B1
Novelty: 0.00167817
Score: 0.964
Data Source: STRINGDB
PDIA6
Family: Enzyme
Novelty: 0.02339159
Score: 0.947
Data Source: STRINGDB
ALB
Novelty: 0.0000092
Score: 0.945
Data Source: STRINGDB
PCSK9
Family: Enzyme
Novelty: 0.00047935
Score: 0.943
Data Source: STRINGDB
FN1
Novelty: 0.0000437
Score: 0.937
Data Source: STRINGDB
FGA
Novelty: 0.00122914
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score 73.66
PubMed score by year
PubTator Score 42.02
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAKTFDQLTPEESK
1-70
ERLGKIVSKIDGDKDGFVTVDELKDWIKFAQKRWIYEDVERQWKGHDLNEDGLVSWEEYKNATYGYVLDD
70-140
PDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDL
140-210
EEYIGDMYSHDGNTDEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQN
210-280
KDGKLTKEEIVDKYDLFVGSQATDFGEALVRHDEF
280-315
MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAKTFDQLTPEESKERLGKIVSKIDGDKDGFVTVDELKDWIKFAQKRWIYEDVERQWKGHDLNEDGLVSWEEYKNATYGYVLDDPDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKDGKLTKEEIVDKYDLFVGSQATDFGEALVRHDEF
Find similar targets by: