Tbio CALU Calumenin

Protein Classes

PANTHER Classes

Protein / Calcium-binding Protein / Intracellular Calcium-sensing Protein / Calmodulin / Calumenin

Protein Summary

Description

Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• O43852
• B3KPG9
• D6QS48
• D6QS49
• D6QS50
• D6QS51
• D6QS52
• D6QS53
• D6QS54
• D6QS55
• D6QS56
• D6QS57
• D6QS58
• D6QS59
• F5H1Q9
• F5H879
• O60456
• Q6FHB9
• Q96RL3
• Q9NR43

Gene Name

• CALU

Ensembl ID

• ENST00000249364
• ENSP00000249364
• ENSG00000128595
• ENST00000449187
• ENSP00000408838
• ENST00000479257
• ENSP00000420381
• ENST00000535011
• ENSP00000442110
• ENST00000542996
• ENSP00000438248

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.99
disease perturbation	0.97
kinase perturbation	0.93
microRNA	0.93
interacting protein	0.87

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.66   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 240   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.66   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (16)

Reactome (8)

WikiPathways (8)

Hemostasis (R-HSA-109582)

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Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Platelet activation, signaling and aggregation	258 targets	R-HSA-76002
Reactome	Platelet degranulation	128 targets	R-HSA-114608
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592

Name	Explore in Pharos	Explore in Source
Hemostasis	666 targets	R-HSA-109582
Metabolism of proteins	2050 targets	R-HSA-392499
Platelet activation, signaling and aggregation	258 targets	R-HSA-76002
Platelet degranulation	128 targets	R-HSA-114608
Post-translational protein modification	1450 targets	R-HSA-597592

Gene Ontology Terms (11)

Functions (1)

Components (8)

Processes (2)

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Direct Assay (IDA)	UniProtKB

Protein-Protein Interactions (198)

Explore Interacting Targets

1 – 10 of 198

• See Interactions on String-DB

IGF2

Tbio

Novelty: 0.00024884

p_int: 0.999758178

p_ni: 0.000241823

Data Source: BioPlex

MRPS7

Tbio

Novelty: 0.00146168

p_int: 0.912880822

p_ni: 0.087119178

Score: 0.249

Data Source: BioPlex,STRINGDB

HIC2

Tbio

Family: TF

Novelty: 0.39202376

p_int: 0.808319625

p_ni: 0.175428987

p_wrong: 0.016251388

Score: 0.282

Data Source: BioPlex,STRINGDB

P4HB

Tbio

Family: Enzyme

Novelty: 0.00117072

Score: 0.991

Data Source: STRINGDB

HSP90B1

Tchem

Novelty: 0.00167817

Score: 0.964

Data Source: STRINGDB

PDIA6

Tchem

Family: Enzyme

Novelty: 0.02339159

Score: 0.947

Data Source: STRINGDB

ALB

Tchem

Novelty: 0.0000092

Score: 0.945

Data Source: STRINGDB

PCSK9

Tclin

Family: Enzyme

Novelty: 0.00047935

Score: 0.943

Data Source: STRINGDB

FN1

Tchem

Novelty: 0.0000437

Score: 0.937

Data Source: STRINGDB

FGA

Tbio

Novelty: 0.00122914

Score: 0.935

Data Source: STRINGDB

Publication Statistics

PubMed Score  73.66

PubMed score by year

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PubTator Score  42.02

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAKTFDQLTPEESK

1-70

ERLGKIVSKIDGDKDGFVTVDELKDWIKFAQKRWIYEDVERQWKGHDLNEDGLVSWEEYKNATYGYVLDD

70-140

PDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDL

140-210

EEYIGDMYSHDGNTDEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQN

210-280

KDGKLTKEEIVDKYDLFVGSQATDFGEALVRHDEF

280-315

MDLRQFLMCLSLCTAFALSKPTEKKDRVHHEPQLSDKVHNDAQSFDYDHDAFLGAEEAKTFDQLTPEESKERLGKIVSKIDGDKDGFVTVDELKDWIKFAQKRWIYEDVERQWKGHDLNEDGLVSWEEYKNATYGYVLDDPDPDDGFNYKQMMVRDERRFKMADKDGDLIATKEEFTAFLHPEEYDYMKDIVVQETMEDIDKNADGFIDLEEYIGDMYSHDGNTDEPEWVKTEREQFVEFRDKNRDGKMDKEETKDWILPSDYDHAEAEARHLVYESDQNKDGKLTKEEIVDKYDLFVGSQATDFGEALVRHDEF

Find similar targets by:

Uniprot Keyword

Acetylation
Alternative splicing
Calcium
Complete proteome
Direct protein sequencing
Endoplasmic reticulum
Glycoprotein
Golgi apparatus
Membrane
Metal-binding