You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CALU
Calumenin

Protein Summary
Description
Involved in regulation of vitamin K-dependent carboxylation of multiple N-terminal glutamate residues. Seems to inhibit gamma-carboxylase GGCX. Binds 7 calcium ions with a low affinity (By similarity). The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.97
kinase perturbation
0.93
microRNA
0.93
interacting protein
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.52   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.52   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
2
3
98.5
mathematical ability
4
2
4
98.5
cognitive function measurement
3
1
3
95.3
intelligence
2
1
1
6.1
76.5
alcohol consumption measurement
1
1
1
47.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
98.5
mathematical ability
4
98.5
cognitive function measurement
3
95.3
intelligence
1
6.1
76.5
alcohol consumption measurement
1
47.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
calumenin
699730
Mouse
MGI:1097158
12321
Rat
RGD:620383
64366
Dog
calumenin
VGNC:54755
475201
Horse
calumenin
100056849
Species
Name
OMA
EggNOG
Inparanoid
Macaque
calumenin
Mouse
Rat
Dog
calumenin
Horse
calumenin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43852-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (16)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Metabolism of proteins
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Hemostasis
Metabolism of proteins
Platelet activation, signaling and aggregation
Platelet degranulation
Post-translational protein modification
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (198)
1 – 10 of 198
IGF2
Tbio
Novelty: 0.00021277
p_int: 0.999758178
p_ni: 0.000241823
Data Source: BioPlex
MRPS7
Tbio
Novelty: 0.00153134
p_int: 0.912880822
p_ni: 0.087119178
Score: 0.249
Data Source: BioPlex,STRINGDB
HIC2
Tbio
Family: TF
Novelty: 0.1544738
p_int: 0.808319625
p_ni: 0.175428987
p_wrong: 0.016251388
Score: 0.282
Data Source: BioPlex,STRINGDB
P4HB
Tbio
Family: Enzyme
Novelty: 0.00107905
Score: 0.991
Data Source: STRINGDB
HSP90B1
Tchem
Novelty: 0.00135881
Score: 0.964
Data Source: STRINGDB
PDIA6
Tchem
Family: Enzyme
Novelty: 0.01692178
Score: 0.947
Data Source: STRINGDB
ALB
Tchem
Novelty: 0.00000616
Score: 0.945
Data Source: STRINGDB
PCSK9
Tclin
Family: Enzyme
Novelty: 0.00030553
Score: 0.943
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.937
Data Source: STRINGDB
FGA
Tbio
Novelty: 0.00107227
Score: 0.935
Data Source: STRINGDB
Publication Statistics
PubMed Score  83.52

PubMed score by year
PubTator Score  42.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: