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Tbio
ZBTB14
Zinc finger and BTB domain-containing protein 14

Protein Summary
Description
Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357006
  • ENSP00000349503
  • ENSG00000198081
  • ENST00000400143
  • ENSP00000383009
  • ENST00000614697
  • ENSP00000484129
  • ENST00000615385
  • ENSP00000478971

Symbol
  • ZFP161
  • ZNF478
  • ZF5
  • ZFP-5
  • ZFP161
  • ZNF478
  • ZFP-161
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
protein domain
0.85
transcription factor binding site profile
0.67
cell type or tissue
0.64
transcription factor
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.13   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.13   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0