Tchem SLC37A4 Glucose-6-phosphate exchanger SLC37A4

Protein Summary

Description

Inorganic phosphate and glucose-6-phosphate antiporter of the endoplasmic reticulum. Transports cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocates inorganic phosphate into the opposite direction. Forms with glucose-6-phosphatase the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it plays a central role in homeostatic regulation of blood glucose levels. This gene regulates glucose-6-phosphate transport from the cytoplasm to the lumen of the endoplasmic reticulum, in order to maintain glucose homeostasis. It also plays a role in ATP-mediated calcium sequestration in the lumen of the endoplasmic reticulum. Mutations in this gene have been associated with various forms of glycogen storage disease. Alternative splicing in this gene results in multiple transcript variants.[provided by RefSeq, Aug 2009]

Uniprot Accession IDs

• O43826
• O96016
• Q5J7V4
• Q9UI19
• Q9UNS4

Gene Name

• SLC37A4

Ensembl ID

• ENST00000631372
• ENSP00000486168
• ENSG00000281500
• ENST00000642844
• ENSP00000493469
• ENST00000644666
• ENSP00000494243
• ENST00000645735
• ENSP00000495653

Symbol

• G6PT
• G6PT1
• G6PT1
• G6PT2
• G6PT3
• GSD1b
• GSD1c
• GSD1d
• TRG19
• TRG-19
• PRO0685

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
transcription factor perturbation	0.8
gene perturbation	0.79
tissue sample	0.69
cellular component	0.67

Protein Classes

PANTHER Classes

Protein / Transporter / Cation Transporter / Glucose-6-phosphate Exchanger Slc37a4

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc37 Family Of Phosphosugar/phosphate Exchangers / Glucose-6-phosphate Exchanger Slc37a4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.82   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 132.82   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0