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Tbio
HYAL3
Hyaluronidase-3

Protein Summary
Description
Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro. This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336307
  • ENSP00000337425
  • ENSG00000186792
  • ENST00000359051
  • ENSP00000351946
  • ENST00000415204
  • ENSP00000401092
  • ENST00000450982
  • ENSP00000391922
  • ENST00000513170
  • ENSP00000424633
  • ENST00000621157
  • ENSP00000479935

Symbol
  • LUCA3
  • LUCA3
  • HYAL-3
  • LUCA-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
protein domain
0.73
gene perturbation
0.71
transcription factor binding site profile
0.7
cell type or tissue
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.44   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.44   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (19)
PTER
Tbio
Family:  Enzyme
Novelty:  0.01347498
p_int:  0.994960389
p_ni:  0.002319703
p_wrong:  0.002719909
Score:  0.252
Data Source:  BioPlex,STRINGDB
CANX
Tbio
Novelty:  0.00087002
p_int:  0.959950718
p_ni:  0.040049282
Score:  0.161
Data Source:  BioPlex,STRINGDB
GUSB
Tchem
Family:  Enzyme
Novelty:  0.00053974
Score:  0.913
Data Source:  STRINGDB
IDUA
Tbio
Family:  Enzyme
Novelty:  0.00288117
Score:  0.902
Data Source:  STRINGDB
ARSB
Tbio
Family:  Enzyme
Novelty:  0.01044355
Score:  0.9
Data Source:  STRINGDB
SPAG9
Tbio
Family:  Enzyme
Novelty:  0.00527315
Score:  0.807
Data Source:  STRINGDB
HAS3
Tbio
Family:  Enzyme
Novelty:  0.03898687
Score:  0.556
Data Source:  STRINGDB
HAS2
Tbio
Family:  Enzyme
Novelty:  0.0025539
Score:  0.5
Data Source:  STRINGDB
IFRD2
Tbio
Novelty:  0.03050513
Score:  0.488
Data Source:  STRINGDB
CYB561D2
Tbio
Novelty:  0.09756816
Score:  0.473
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
CS/DS degradation (R-HSA-2024101)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
CS/DS degradation
Reactome
Chondroitin sulfate/dermatan sulfate metabolism
Reactome
Glycosaminoglycan metabolism
Reactome
Hyaluronan metabolism
Reactome
Hyaluronan uptake and degradation
Name
Explore in Pharos
Explore in Source
CS/DS degradation
Chondroitin sulfate/dermatan sulfate metabolism
Glycosaminoglycan metabolism
Hyaluronan metabolism
Hyaluronan uptake and degradation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
7
14
99.5
reticulocyte count
2
4
8
98.7
mean reticulocyte volume
1
1
1
85.1
chronotype measurement
1
2
0
1
78.7
macrophage inflammatory protein 1b measurement
1
2
2
66.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
14
99.5
reticulocyte count
8
98.7
mean reticulocyte volume
1
85.1
chronotype measurement
0
1
78.7
macrophage inflammatory protein 1b measurement
2
66.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1330288
109685
Rat
RGD:1303334
300993
Horse
hyaluronoglucosaminidase 3
VGNC:18918
100061939
Pig
hyaluronoglucosaminidase 3
404696
Opossum
hyaluronoglucosaminidase 3
100028570
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
hyaluronoglucosaminidase 3
Pig
hyaluronoglucosaminidase 3
Opossum
hyaluronoglucosaminidase 3
Publication Statistics
PubMed Score 7.44
PubMed score by year
PubTator Score 16.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title