Tbio HYAL3 Hyaluronidase-3

Protein Summary

Description

Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro. This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• O43820
• O60540
• Q8NFK2
• Q8NFK3
• Q8NFK4
• Q96E56
• Q9BRW9
• Hyal-3

Gene Name

• HYAL3

Ensembl ID

• ENST00000336307
• ENSP00000337425
• ENSG00000186792
• ENST00000359051
• ENSP00000351946
• ENST00000415204
• ENSP00000401092
• ENST00000450982
• ENSP00000391922
• ENST00000513170
• ENSP00000424633
• ENST00000621157
• ENSP00000479935

Symbol

• LUCA3
• LUCA3
• HYAL-3
• LUCA-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.89
protein domain	0.73
gene perturbation	0.71
transcription factor binding site profile	0.7
cell type or tissue	0.67

Protein Classes

PANTHER Classes

Protein / Receptor / Hyaluronidase-3

Protein / Hydrolase / Glycosidase / Hyaluronidase-3

DTO Classes

Protein / Enzyme / Hydrolase / Glycosidase / Hyaluronidase-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.79   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 169   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.79   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0