Protein Summary
Facilitates sperm penetration into the layer of cumulus cells surrounding the egg by digesting hyaluronic acid. Involved in induction of the acrosome reaction in the sperm. Involved in follicular atresia, the breakdown of immature ovarian follicles that are not selected to ovulate. Induces ovarian granulosa cell apoptosis, possibly via apoptotic signaling pathway involving CASP8 and CASP3 activation, and poly(ADP-ribose) polymerase (PARP) cleavage. Has no hyaluronidase activity in embryonic fibroblasts in vitro. Has no hyaluronidase activity in granulosa cells in vitro. This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is o ...more
- ENST00000336307
- ENSP00000337425
- ENSG00000186792
- ENST00000359051
- ENSP00000351946
- ENST00000415204
- ENSP00000401092
- ENST00000450982
- ENSP00000391922
- ENST00000513170
- ENSP00000424633
- ENST00000621157
- ENSP00000479935
- LUCA3
- LUCA3
- HYAL-3
- LUCA-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.89 | ||
protein domain | 0.73 | ||
gene perturbation | 0.71 | ||
transcription factor binding site profile | 0.7 | ||
cell type or tissue | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.44 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 169 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 7.44 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 169 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (19)
Nearest Tclin Targets
Pathways (9)
Reactome (7)
KEGG (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | CS/DS degradation | ||||
Reactome | Chondroitin sulfate/dermatan sulfate metabolism | ||||
Reactome | Glycosaminoglycan metabolism | ||||
Reactome | Hyaluronan metabolism | ||||
Reactome | Hyaluronan uptake and degradation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
CS/DS degradation | ||||
Chondroitin sulfate/dermatan sulfate metabolism | ||||
Glycosaminoglycan metabolism | ||||
Hyaluronan metabolism | ||||
Hyaluronan uptake and degradation | ||||
Viral Interactions (0)
Gene Ontology Terms (25)
Functions (2)
Components (9)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (20)
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 7 | 14 | 99.5 | |||||
reticulocyte count | 2 | 4 | 8 | 98.7 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 85.1 | |||||
chronotype measurement | 1 | 2 | 0 | 1 | 78.7 | ||||
macrophage inflammatory protein 1b measurement | 1 | 2 | 2 | 66.2 | |||||
Items per page:
1 – 5 of 20
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 14 | 99.5 | |||||
reticulocyte count | 8 | 98.7 | |||||
mean reticulocyte volume | 1 | 85.1 | |||||
chronotype measurement | 0 | 1 | 78.7 | ||||
macrophage inflammatory protein 1b measurement | 2 | 66.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1330288 | 109685 | ||||||
Rat | RGD:1303334 | 300993 | ||||||
Horse | hyaluronoglucosaminidase 3 | VGNC:18918 | 100061939 | |||||
Pig | hyaluronoglucosaminidase 3 | 404696 | ||||||
Opossum | hyaluronoglucosaminidase 3 | 100028570 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Horse | hyaluronoglucosaminidase 3 | |||||
Pig | hyaluronoglucosaminidase 3 | |||||
Opossum | hyaluronoglucosaminidase 3 | |||||
Publication Statistics
PubMed Score 7.44
PubMed score by year
PubTator Score 16.29
PubTator score by year
Related Publications
Text Mined References (27)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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