Tbio SCO2 Protein SCO2 homolog, mitochondrial

Protein Summary

Description

Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Involved in transporting copper to the Cu(A) site on MT-CO2/COX2 (PubMed:15229189, PubMed:17189203). Also acts as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2 (PubMed:19336478). Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX assembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy and myopia 6. [provided by RefSeq, Oct 2014]

Uniprot Accession IDs

• O43819
• Q3T1B5
• Q9UK87

Gene Name

• SCO2

Ensembl ID

• ENST00000252785
• ENSP00000252785
• ENSG00000130489
• ENST00000395693
• ENSP00000379046

Symbol

• TP
• MYP6
• TYMP
• ECGF1
• SCO1L
• CEMCOX1
• PD-ECGF
• TdRPase
• Gliostatin

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.97
kinase perturbation	0.93
interacting protein	0.82
transcription factor perturbation	0.68
transcription factor binding site profile	0.65

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxidase / Protein Sco2 Homolog, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxidase / Protein Sco2 Homolog, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.17   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.17   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0