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Tbio
STRN
Striatin

Protein Summary
Description
Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263918
  • ENSP00000263918
  • ENSG00000115808
  • ENST00000379213
  • ENSP00000368513

Symbol
  • SG2NA
  • STRN1
  • PPP2R6A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
disease perturbation
0.9
histone modification site profile
0.86
microRNA
0.85
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.5   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.5   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
1
3
0
5.6
95.1
mean platelet volume
3
2
3
89.5
C-reactive protein measurement
1
1
1
85.7
red blood cell distribution width
2
1
2
57.7
triglyceride measurement
2
2
2
51.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
0
5.6
95.1
mean platelet volume
3
89.5
C-reactive protein measurement
1
85.7
red blood cell distribution width
2
57.7
triglyceride measurement
2
51.3
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
striatin
VGNC:10777
470350
Macaque
striatin
708491
Mouse
MGI:1333757
268980
Rat
RGD:3782
29149
Dog
striatin
VGNC:46945
100683096
Species
Name
OMA
EggNOG
Inparanoid
Chimp
striatin
Macaque
striatin
Mouse
Rat
Dog
striatin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43815-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (197)
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
ESR-mediated signaling
Reactome
Extra-nuclear estrogen signaling
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer
Disease
Diseases of signal transduction
ESR-mediated signaling
Extra-nuclear estrogen signaling
Gene Ontology Terms (19)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (138)
1 – 10 of 138
SLMAP
Tbio
Novelty: 0.03974856
p_int: 0.999999988
p_ni: 1.3e-8
Score: 0.974
Data Source: BioPlex,STRINGDB
SIKE1
Tbio
Novelty: 0.14549184
p_int: 0.999999954
p_ni: 4.7e-8
Score: 0.941
Data Source: BioPlex,STRINGDB
MOB4
Tbio
Novelty: 0.03238981
p_int: 0.999999886
p_ni: 8.3e-8
p_wrong: 3.1e-8
Score: 0.995
Data Source: BioPlex,STRINGDB
STRN4
Tbio
Novelty: 0.09936184
p_int: 0.999999441
p_ni: 5.59e-7
Score: 0.87
Data Source: BioPlex,STRINGDB
STRN3
Tbio
Novelty: 0.10331283
p_int: 0.999998505
p_ni: 0.000001495
Score: 0.865
Data Source: BioPlex,STRINGDB
STRIP1
Tbio
Novelty: 0.13320106
p_int: 0.999998297
p_ni: 0.000001703
Score: 0.976
Data Source: BioPlex,STRINGDB
TRAF3IP3
Tbio
Novelty: 0.12180834
p_int: 0.999998045
p_ni: 0.000001955
Score: 0.865
Data Source: BioPlex,STRINGDB
CTTNBP2NL
Tbio
Novelty: 0.52774527
p_int: 0.999997694
p_ni: 0.000002306
Score: 0.954
Data Source: BioPlex,STRINGDB
CTTNBP2
Tbio
Novelty: 0.00241
p_int: 0.999996994
p_ni: 0.000003006
Score: 0.947
Data Source: BioPlex,STRINGDB
PPP2CB
Tbio
Family: Enzyme
Novelty: 0.0483178
p_int: 0.999988373
p_ni: 0.000011627
Score: 0.932
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  105.50

PubMed score by year
PubTator Score  31.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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