Tbio LANCL1 LanC-like protein 1

Protein Summary

Description

May play a role in EPS8 signaling. Binds glutathione. This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]

Uniprot Accession IDs

• O43813

Gene Name

• LANCL1

Ensembl ID

• ENST00000233714
• ENSP00000233714
• ENSG00000115365
• ENST00000431941
• ENSP00000397646
• ENST00000441020
• ENSP00000393323
• ENST00000443314
• ENSP00000388713
• ENST00000450366
• ENSP00000393597

Symbol

• GPR69A
• p40
• GPR69A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	0.99
transcription factor perturbation	0.96
molecular function	0.88
co-expressed gene	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.9   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 101   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.9   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0