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Tbio
LANCL1
LanC-like protein 1

Protein Summary
Description
May play a role in EPS8 signaling. Binds glutathione. This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233714
  • ENSP00000233714
  • ENSG00000115365
  • ENST00000431941
  • ENSP00000397646
  • ENST00000441020
  • ENSP00000393323
  • ENST00000443314
  • ENSP00000388713
  • ENST00000450366
  • ENSP00000393597

Symbol
  • GPR69A
  • p40
  • GPR69A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.99
transcription factor perturbation
0.96
molecular function
0.88
co-expressed gene
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.48   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.48   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (36)
1 – 10 of 36
FIGN
Tbio
Family:  Enzyme
Novelty:  0.02804869
p_int:  0.999999995
p_ni:  3e-9
p_wrong:  2e-9
Score:  0.516
Data Source:  BioPlex,STRINGDB
DERA
Tbio
Family:  Enzyme
Novelty:  0.0079635
p_int:  0.999996225
p_ni:  0.000003775
Score:  0.226
Data Source:  BioPlex,STRINGDB
IPP
Tbio
Novelty:  0.12841634
p_int:  0.999994435
p_ni:  0.000005565
Score:  0.295
Data Source:  BioPlex,STRINGDB
ALDH16A1
Tdark
Family:  Enzyme
Novelty:  0.21880567
p_int:  0.999987159
p_ni:  0.000012841
Score:  0.228
Data Source:  BioPlex,STRINGDB
UBN2
Tbio
Novelty:  0.09777456
p_int:  0.999422624
p_ni:  0.000577374
p_wrong:  1e-9
Score:  0.523
Data Source:  BioPlex,STRINGDB
TBC1D9
Tbio
Novelty:  0.20059899
p_int:  0.99891006
p_ni:  0.001089765
p_wrong:  1.75e-7
Score:  0.692
Data Source:  BioPlex,STRINGDB
TBC1D9B
Tdark
Novelty:  0.66719861
p_int:  0.998703265
p_ni:  0.001296735
Score:  0.558
Data Source:  BioPlex,STRINGDB
MYO7A
Tbio
Novelty:  0.00314435
p_int:  0.960189819
p_ni:  0.000034848
p_wrong:  0.039775332
Score:  0.56
Data Source:  BioPlex,STRINGDB
STOM
Tbio
Novelty:  0.00459891
Score:  0.838
Data Source:  STRINGDB
EPS8
Tbio
Family:  Enzyme
Novelty:  0.01023541
Score:  0.647
Data Source:  STRINGDB
Gene Ontology Terms (10)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
1
1
1
55.2
glomerular filtration rate
1
1
1
54.4
body height
1
1
1
31.4
sex hormone-binding globulin measurement
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatinine measurement
1
55.2
glomerular filtration rate
1
54.4
body height
1
31.4
sex hormone-binding globulin measurement
1
15.8
Find similar targets by:
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LanC like 1
VGNC:6367
459917
Mouse
MGI:1336997
14768
Rat
RGD:69416
114515
Dog
LanC like 1
VGNC:42580
478897
Horse
LanC like 1
VGNC:19578
100050050
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LanC like 1
Mouse
Rat
Dog
LanC like 1
Horse
LanC like 1
Publication Statistics
PubMed Score 17.48
PubMed score by year
PubTator Score 10.04
PubTator score by year