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Tbio
NARS
Asparagine--tRNA ligase, cytoplasmic

Protein Summary
Description
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256854
  • ENSP00000256854
  • ENSG00000134440
  • ENST00000540592
  • ENSP00000442496

Symbol
  • ASNRS
  • NARS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
interacting protein
0.93
protein domain
0.92
molecular function
0.9


Related Tools
GENEVA
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.23   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.23   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
asparaginyl-tRNA synthetase
VGNC:13272
455438
Macaque
asparaginyl-tRNA synthetase
695872
Mouse
MGI:1917473
70223
Rat
RGD:1307238
291556
Dog
asparaginyl-tRNA synthetase
VGNC:43625
607631
Species
Name
OMA
EggNOG
Inparanoid
Chimp
asparaginyl-tRNA synthetase
Macaque
asparaginyl-tRNA synthetase
Mouse
Rat
Dog
asparaginyl-tRNA synthetase
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism of proteins
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism of proteins
Translation
tRNA Aminoacylation
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (130)
1 – 10 of 130
FGB
Tbio
Novelty: 0.00437751
p_int: 0.999324385
p_ni: 0.000675615
Data Source: BioPlex
GTF2E2
Tbio
Novelty: 0.18033153
p_int: 0.998964892
p_ni: 0.001035104
p_wrong: 5e-9
Data Source: BioPlex
LILRA3
Tdark
p_int: 0.998794478
p_ni: 0.001205521
Data Source: BioPlex
FAM24B
Tdark
Novelty: 1.04675689
p_int: 0.997068534
p_ni: 0.002931416
p_wrong: 5.1e-8
Data Source: BioPlex
SNRNP27
Tbio
Novelty: 0.0175187
p_int: 0.994713718
p_ni: 0.005286281
Score: 0.196
Data Source: BioPlex,STRINGDB
TRMT11
Tbio
Family: Enzyme
Novelty: 0.11506701
p_int: 0.990921302
p_ni: 0.009078695
p_wrong: 2e-9
Score: 0.256
Data Source: BioPlex,STRINGDB
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.987481303
p_ni: 0.005827792
p_wrong: 0.006690905
Data Source: BioPlex
KLHL20
Tbio
Novelty: 0.12205871
p_int: 0.97692471
p_ni: 0.023075047
p_wrong: 2.43e-7
Data Source: BioPlex
CD226
Tbio
Novelty: 0.00374102
p_int: 0.963202023
p_ni: 0.033716889
p_wrong: 0.003081088
Data Source: BioPlex
USP47
Tchem
Family: Enzyme
Novelty: 0.07579226
p_int: 0.962167079
p_ni: 0.037832868
p_wrong: 5.2e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  84.23

PubMed score by year
PubTator Score  13.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer