Tbio NARS Asparagine--tRNA ligase, cytoplasmic

Protein Summary

Description

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Asparaginyl-tRNA synthetase is localized to the cytoplasm and belongs to the class II family of tRNA synthetases. The N-terminal domain represents the signature sequence for the eukaryotic asparaginyl-tRNA synthetases. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43776
• B4DG16
• Q53GU6

Gene Name

• NARS

Ensembl ID

• ENST00000256854
• ENSP00000256854
• ENSG00000134440
• ENST00000540592
• ENSP00000442496

Symbol

• ASNRS
• NARS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	1
interacting protein	0.93
protein domain	0.92
molecular function	0.9

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Asparagine--trna Ligase, Cytoplasmic

Protein / Ligase / Aminoacyl-trna Synthetase / Asparagine--trna Ligase, Cytoplasmic

DTO Classes

Protein / Enzyme / Ligase / Aminoacyl-trna Synthetase / Asparagine--trna Ligase, Cytoplasmic

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.57   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 173   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 145.57   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0