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Tbio
SLC25A20
Mitochondrial carnitine/acylcarnitine carrier protein

Protein Summary
Description
Mediates the transport of acylcarnitines of different length across the mitochondrial inner membrane from the cytosol to the mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. This gene product is one of several closely related mitochondrial-membrane carrier proteins that shuttle substrates between cytosol and the intramitochondrial matrix space. This protein mediates the transport of acylcarnitines into mitochondrial matrix for their oxidation by the mitochondrial fatty acid-oxidation pathway. Mutations in this gene are associated with carnitine-acylcarnitine translocase deficiency, which can cause a variety of pathological conditions such as hypoglycemia, cardiac arrest, hepatomegaly, hepatic dysfunction and muscle weakness, and is usually lethal in new born and infants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319017
  • ENSP00000326305
  • ENSG00000178537

Symbol
  • CAC
  • CACT
  • CAC
  • CACT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
disease perturbation
0.93
PubMedID
0.79
cell type or tissue
0.78
cellular component
0.77


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.78   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 190.78   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cigarettes per day measurement
1
1
1
78.1
reticulocyte measurement
2
2
2
46.9
eosinophil percentage of leukocytes
1
1
1
32.6
reticulocyte count
1
1
1
29.6
insomnia measurement
1
1
0
1.1
5.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cigarettes per day measurement
1
78.1
reticulocyte measurement
2
46.9
eosinophil percentage of leukocytes
1
32.6
reticulocyte count
1
29.6
insomnia measurement
0
1.1
5.8
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 20
VGNC:8008
460354
Macaque
solute carrier family 25 member 20
709029
Mouse
MGI:1928738
57279
Rat
RGD:621443
117035
Dog
solute carrier family 25 member 20
VGNC:46299
484774
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 20
Macaque
solute carrier family 25 member 20
Mouse
Rat
Dog
solute carrier family 25 member 20
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43772-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Import of palmitoyl-CoA into the mitochondrial matrix
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Import of palmitoyl-CoA into the mitochondrial matrix
Metabolism
Metabolism of lipids
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Protein-Protein Interactions (89)
1 – 10 of 89
MMP26
Tchem
Family: Enzyme
Novelty: 0.02180874
p_int: 0.999103976
p_ni: 0.000895447
p_wrong: 5.77e-7
Score: 0.165
Data Source: BioPlex,STRINGDB
FIS1
Tbio
Novelty: 0.0033607
p_int: 0.996914223
p_ni: 0.003085033
p_wrong: 7.45e-7
Data Source: BioPlex
GLMP
Tdark
Novelty: 0.10163099
p_int: 0.992272942
p_ni: 0.005072748
p_wrong: 0.00265431
Data Source: BioPlex
ARL15
Tbio
Family: Enzyme
Novelty: 0.09327102
p_int: 0.991669268
p_ni: 0.005884158
p_wrong: 0.002446574
Score: 0.161
Data Source: BioPlex,STRINGDB
KLK1
Tchem
Family: Enzyme
Novelty: 0.00190157
p_int: 0.990766285
p_ni: 0.009073019
p_wrong: 0.000160696
Data Source: BioPlex
MGARP
Tbio
Novelty: 0.02883753
p_int: 0.990692383
p_ni: 0.009306741
p_wrong: 8.76e-7
Data Source: BioPlex
ISLR
Tbio
Novelty: 0.02936208
p_int: 0.988469419
p_ni: 0.008854311
p_wrong: 0.00267627
Data Source: BioPlex
NIT1
Tbio
Family: Enzyme
Novelty: 0.00498587
p_int: 0.987995977
p_ni: 0.009978504
p_wrong: 0.002025519
Score: 0.196
Data Source: BioPlex,STRINGDB
CLEC2D
Tbio
Novelty: 0.02501194
p_int: 0.984799663
p_ni: 0.015072541
p_wrong: 0.000127796
Data Source: BioPlex
MRAP2
Tbio
Novelty: 0.0420503
p_int: 0.978826678
p_ni: 0.020828412
p_wrong: 0.00034491
Data Source: BioPlex
Publication Statistics
PubMed Score  190.78

PubMed score by year
PubTator Score  84.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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