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Tbio
SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

Protein Summary
Description
Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892, PubMed:25535373). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Bind ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221566
  • ENSP00000221566
  • ENSG00000104969

Symbol
  • SGT
  • SGT1
  • SGT
  • hSGT
  • alphaSGT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
transcription factor binding site profile
0.84
small molecule perturbation
0.75
disease perturbation
0.68
histone modification site profile
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.07   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 75.07   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
3
6
97.4
testosterone measurement
4
4
4
91.8
low density lipoprotein cholesterol measurement
3
3
3
64.3
total cholesterol measurement
2
2
2
63.6
platelet crit
1
1
1
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
97.4
testosterone measurement
4
91.8
low density lipoprotein cholesterol measurement
3
64.3
total cholesterol measurement
2
63.6
platelet crit
1
61.4
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
small glutamine rich tetratricopeptide repeat containing alpha
VGNC:7542
100609678
Macaque
small glutamine rich tetratricopeptide repeat containing alpha
721574
Mouse
MGI:1098703
52551
Rat
RGD:620815
64667
Dog
small glutamine rich tetratricopeptide repeat containing alpha
VGNC:46107
485067
Species
Name
OMA
EggNOG
Inparanoid
Chimp
small glutamine rich tetratricopeptide repeat containing alpha
Macaque
small glutamine rich tetratricopeptide repeat containing alpha
Mouse
Rat
Dog
small glutamine rich tetratricopeptide repeat containing alpha
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43765-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (2)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (R-HSA-9609523)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Protein localization
Protein-Protein Interactions (102)
1 – 10 of 102
GET4
Tbio
Novelty:  0.03516005
Score:  0.933
Data Source:  Reactome,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
Score:  0.897
Data Source:  STRINGDB
UBL4A
Tbio
Novelty:  0.01278608
Score:  0.893
Data Source:  Reactome,STRINGDB
ASNA1
Tbio
Family:  Enzyme
Novelty:  0.01260233
Score:  0.89
Data Source:  Reactome,STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.837
Data Source:  STRINGDB
HSP90AA1
Tchem
Novelty:  0.00016774
Score:  0.82
Data Source:  STRINGDB
HSPA4
Tbio
Novelty:  0.00009122
Score:  0.802
Data Source:  STRINGDB
DNAJC5
Tbio
Novelty:  0.00091288
Score:  0.802
Data Source:  STRINGDB
ADRM1
Tbio
Novelty:  0.01545209
Score:  0.769
Data Source:  STRINGDB
DNAJC5B
Tdark
Novelty:  0.28962584
Score:  0.753
Data Source:  STRINGDB
Publication Statistics
PubMed Score  75.07

PubMed score by year
PubTator Score  34.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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