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Tbio
SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

Protein Summary
Description
Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:28104892, PubMed:25535373). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Bind ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221566
  • ENSP00000221566
  • ENSG00000104969

Symbol
  • SGT
  • SGT1
  • SGT
  • hSGT
  • alphaSGT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
transcription factor binding site profile
0.84
small molecule perturbation
0.75
disease perturbation
0.68
histone modification site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.83   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 246   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.83   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 246   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (2)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (R-HSA-9609523)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Protein localization
Protein-Protein Interactions (102)
1 – 10 of 102
GET4
Tbio
Novelty: 0.00182534
Score: 0.933
Data Source: Reactome,STRINGDB
HSPA8
Tchem
Novelty: 0.00100906
Score: 0.897
Data Source: STRINGDB
UBL4A
Tbio
Novelty: 0.00409532
Score: 0.893
Data Source: Reactome,STRINGDB
ASNA1
Tbio
Family: Enzyme
Novelty: 0.0127531
Score: 0.89
Data Source: Reactome,STRINGDB
CUL1
Tbio
Novelty: 0.00339576
Score: 0.837
Data Source: STRINGDB
HSP90AA1
Tchem
Novelty: 0.00020424
Score: 0.82
Data Source: STRINGDB
HSPA4
Tbio
Novelty: 0.00010789
Score: 0.802
Data Source: STRINGDB
DNAJC5
Tbio
Novelty: 0.01007956
Score: 0.802
Data Source: STRINGDB
ADRM1
Tbio
Novelty: 0.02083457
Score: 0.769
Data Source: STRINGDB
DNAJC5B
Tdark
Novelty: 0.27231467
Score: 0.753
Data Source: STRINGDB
Publication Statistics
PubMed Score  259.83

PubMed score by year
PubTator Score  34.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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