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Tbio
SYNGR1
Synaptogyrin-1

Protein Summary
Description
May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short-term and long-term synaptic plasticity (By similarity). This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318801
  • ENSP00000318845
  • ENSG00000100321
  • ENST00000328933
  • ENSP00000332287
  • ENST00000381535
  • ENSP00000370946
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
PubMedID
0.89
transcription factor
0.81
histone modification site profile
0.71
kinase perturbation
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.54   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.54   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.3
88.2
3
1
2
1.1
76.9
intelligence
1
1
0
5.5
55.2
esterified cholesterol measurement
1
1
1
25.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
88.2
2
1.1
76.9
intelligence
0
5.5
55.2
esterified cholesterol measurement
1
25.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
synaptogyrin 1
VGNC:12929
100192454
Macaque
synaptogyrin 1
100427479
Mouse
MGI:1328323
20972
Rat
RGD:3801
29205
Horse
synaptogyrin 1 [Source:HGNC Symbol;Acc:HGNC:11498]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
synaptogyrin 1
Macaque
synaptogyrin 1
Mouse
Rat
Horse
synaptogyrin 1 [Source:HGNC Symbol;Acc:HGNC:11498]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43759-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (15)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (84)
1 – 10 of 84
YIPF3
Tbio
Novelty: 0.12021667
p_int: 0.877820986
p_ni: 0.05035202
p_wrong: 0.071826995
Score: 0.189
Data Source: BioPlex,STRINGDB
SYNPR
Tbio
Novelty: 0.04046273
Score: 0.931
Data Source: STRINGDB
SNAP29
Tbio
Novelty: 0.02009206
Score: 0.924
Data Source: STRINGDB
RAB3D
Tbio
Family: Enzyme
Novelty: 0.00921936
Score: 0.923
Data Source: STRINGDB
B4GALT1
Tbio
Family: Enzyme
Novelty: 0.0073693
Score: 0.915
Data Source: STRINGDB
VAMP8
Tbio
Novelty: 0.01083228
Score: 0.912
Data Source: STRINGDB
C3AR1
Tchem
Family: GPCR
Novelty: 0.00527301
Score: 0.908
Data Source: STRINGDB
VAPA
Tbio
Novelty: 0.00169209
Score: 0.908
Data Source: STRINGDB
CMTM6
Tbio
Novelty: 0.05496447
Score: 0.907
Data Source: STRINGDB
PSEN1
Tchem
Family: Enzyme
Novelty: 0.00024189
Score: 0.906
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.54

PubMed score by year
PubTator Score  9.37

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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