Protein Classes
Protein Summary
May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short-term and long-term synaptic plasticity (By similarity). This gene encodes an integral membrane protein associated with presynaptic vesicles in neuronal cells. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it functions in synaptic plasticity without being required for synaptic transmission. The gene product belongs to the synaptogyrin gene family. Three alternatively spliced variants encoding three different isoforms have been identified. [provided by RefSeq, Jul 2008]
- ENST00000318801
- ENSP00000318845
- ENSG00000100321
- ENST00000328933
- ENSP00000332287
- ENST00000381535
- ENSP00000370946
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.96 | ||
PubMedID | 0.89 | ||
transcription factor | 0.81 | ||
histone modification site profile | 0.71 | ||
kinase perturbation | 0.66 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.54 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 159 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.54 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 159 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.3 | 88.2 | |||||
3 | 1 | 2 | 1.1 | 76.9 | |||||
intelligence | 1 | 1 | 0 | 5.5 | 55.2 | ||||
esterified cholesterol measurement | 1 | 1 | 1 | 25.2 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.3 | 88.2 | |||||
2 | 1.1 | 76.9 | |||||
intelligence | 0 | 5.5 | 55.2 | ||||
esterified cholesterol measurement | 1 | 25.2 | |||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | synaptogyrin 1 | VGNC:12929 | 100192454 | |||||
Macaque | synaptogyrin 1 | 100427479 | ||||||
Mouse | MGI:1328323 | 20972 | ||||||
Rat | RGD:3801 | 29205 | ||||||
Horse | synaptogyrin 1 [Source:HGNC Symbol;Acc:HGNC:11498] | |||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | synaptogyrin 1 | |||||
Macaque | synaptogyrin 1 | |||||
Mouse | ||||||
Rat | ||||||
Horse | synaptogyrin 1 [Source:HGNC Symbol;Acc:HGNC:11498] | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 3 of 3
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Reactome | Neutrophil degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Immune System | ||||
Innate Immune System | ||||
Neutrophil degranulation | ||||
Gene Ontology Terms (15)
Components (8)
Processes (7)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Protein-Protein Interactions (84)
1 – 10 of 84
YIPF3
Novelty: 0.12021667
p_int: 0.877820986
p_ni: 0.05035202
p_wrong: 0.071826995
Score: 0.189
Data Source: BioPlex,STRINGDB
SYNPR
Novelty: 0.04046273
Score: 0.931
Data Source: STRINGDB
SNAP29
Novelty: 0.02009206
Score: 0.924
Data Source: STRINGDB
RAB3D
Family: Enzyme
Novelty: 0.00921936
Score: 0.923
Data Source: STRINGDB
B4GALT1
Family: Enzyme
Novelty: 0.0073693
Score: 0.915
Data Source: STRINGDB
VAMP8
Novelty: 0.01083228
Score: 0.912
Data Source: STRINGDB
C3AR1
Family: GPCR
Novelty: 0.00527301
Score: 0.908
Data Source: STRINGDB
VAPA
Novelty: 0.00169209
Score: 0.908
Data Source: STRINGDB
CMTM6
Novelty: 0.05496447
Score: 0.907
Data Source: STRINGDB
PSEN1
Family: Enzyme
Novelty: 0.00024189
Score: 0.906
Data Source: STRINGDB
Publication Statistics
PubMed Score 13.54
PubMed score by year
PubTator Score 9.37
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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