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Tbio
STX6
Syntaxin-6

Protein Summary
Description
Involved in intracellular vesicle trafficking.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258301
  • ENSP00000258301
  • ENSG00000135823
  • ENST00000542060
  • ENSP00000440188
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
cellular component
0.94
transcription factor perturbation
0.88
transcription factor binding site profile
0.77
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.71   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 270   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.71   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Progressive supranuclear palsy
1
1
0
1.3
67.8
sporadic Creutzfeld Jacob disease
1
1
0
1.1
66.3
age at menopause
1
1
1
40.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Progressive supranuclear palsy
0
1.3
67.8
sporadic Creutzfeld Jacob disease
0
1.1
66.3
age at menopause
1
40.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
syntaxin 6
VGNC:1651
457561
Macaque
syntaxin 6
716157
Mouse
MGI:1926235
58244
Rat
RGD:61915
60562
Dog
syntaxin 6
490303
Species
Name
OMA
EggNOG
Inparanoid
Chimp
syntaxin 6
Macaque
syntaxin 6
Mouse
Rat
Dog
syntaxin 6
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43752-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Intra-Golgi traffic
Reactome
Membrane Trafficking
Reactome
Retrograde transport at the Trans-Golgi-Network
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic
Intra-Golgi traffic
Membrane Trafficking
Retrograde transport at the Trans-Golgi-Network
Vesicle-mediated transport
Gene Ontology Terms (30)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (193)
1 – 10 of 193
STX7
Tbio
Novelty: 0.03109969
p_int: 0.999999949
p_ni: 5.1e-8
Score: 0.981
Data Source: BioPlex,STRINGDB
STX12
Tbio
Novelty: 0.03836262
p_int: 0.999998537
p_ni: 0.000001463
Score: 0.994
Data Source: BioPlex,STRINGDB
CLEC12A
Tbio
Novelty: 0.01478908
p_int: 0.999981303
p_ni: 0.000018695
p_wrong: 2e-9
Score: 0.632
Data Source: BioPlex,STRINGDB
STX3
Tbio
Novelty: 0.01055819
p_int: 0.999979536
p_ni: 0.000020182
p_wrong: 2.82e-7
Score: 0.974
Data Source: BioPlex,STRINGDB
VTI1A
Tbio
Novelty: 0.04616617
p_int: 0.999970335
p_ni: 0.000029635
p_wrong: 3e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
VAMP8
Tbio
Novelty: 0.01083228
p_int: 0.999961679
p_ni: 0.000038282
p_wrong: 3.9e-8
Score: 0.995
Data Source: BioPlex,STRINGDB
GOSR2
Tbio
Novelty: 0.02447711
p_int: 0.999955537
p_ni: 0.000044463
Score: 0.983
Data Source: BioPlex,STRINGDB
STX18
Tbio
Novelty: 0.0259034
p_int: 0.999903409
p_ni: 0.000096591
Score: 0.955
Data Source: BioPlex,STRINGDB
VTI1B
Tbio
Novelty: 0.00955467
p_int: 0.999898387
p_ni: 0.000101613
Score: 0.991
Data Source: BioPlex,STRINGDB
STXBP5
Tbio
Novelty: 0.01899802
p_int: 0.999865309
p_ni: 0.000134673
p_wrong: 1.8e-8
Score: 0.855
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  56.71

PubMed score by year
PubTator Score  44.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer