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Tbio
AP1G1
AP-1 complex subunit gamma-1

Protein Summary
Description
Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299980
  • ENSP00000299980
  • ENSG00000166747
  • ENST00000393512
  • ENSP00000377148
  • ENST00000569748
  • ENSP00000454523

Symbol
  • ADTG
  • CLAPG1
  • ADTG
  • CLAPG1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
transcription factor perturbation
0.94
protein domain
0.92
transcription factor binding site profile
0.89
disease perturbation
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.52   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 223   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.52   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
2
2
2
91.1
mathematical ability
1
1
1
7.6
self reported educational attainment
1
1
1
5.4
high density lipoprotein cholesterol measurement
1
1
1
3.4
intelligence
1
1
0
5.6
1.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
2
91.1
mathematical ability
1
7.6
self reported educational attainment
1
5.4
high density lipoprotein cholesterol measurement
1
3.4
intelligence
0
5.6
1.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 1 subunit gamma 1
VGNC:8958
454228
Macaque
adaptor related protein complex 1 gamma 1 subunit
710171
Mouse
MGI:101919
11765
Dog
adaptor related protein complex 1 subunit gamma 1
VGNC:37952
479666
Horse
adaptor related protein complex 1 subunit gamma 1
VGNC:15373
100054483
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adaptor related protein complex 1 subunit gamma 1
Macaque
adaptor related protein complex 1 gamma 1 subunit
Mouse
Dog
adaptor related protein complex 1 subunit gamma 1
Horse
adaptor related protein complex 1 subunit gamma 1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Disease
Reactome
Golgi Associated Vesicle Biogenesis
Reactome
HIV Infection
Reactome
Host Interactions of HIV factors
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Disease
Golgi Associated Vesicle Biogenesis
HIV Infection
Host Interactions of HIV factors
Gene Ontology Terms (26)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (220)
1 – 10 of 220
AP1S2
Tbio
Novelty: 0.01413503
p_int: 0.999999954
p_ni: 4.6e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
AP1S3
Tbio
Novelty: 0.14425094
p_int: 0.999994179
p_ni: 0.000005821
Score: 0.99
Data Source: BioPlex,Reactome,STRINGDB
AP1M2
Tbio
Novelty: 0.02984354
p_int: 0.999985763
p_ni: 0.000014237
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.99943198
p_ni: 0.00056802
Score: 0.936
Data Source: BioPlex,STRINGDB
AAGAB
Tbio
Novelty: 0.0479209
p_int: 0.999146486
p_ni: 0.000853514
Score: 0.612
Data Source: BioPlex,STRINGDB
POTEB
Tdark
Novelty: 0.48864918
p_int: 0.900869738
p_ni: 0.099130262
Data Source: BioPlex
PPP6R2
Tbio
Family: Enzyme
Novelty: 0.12886225
p_int: 0.893488663
p_ni: 0.106511337
Score: 0.566
Data Source: BioPlex,STRINGDB
AP1S1
Tbio
Novelty: 0.01740202
Score: 0.999
Data Source: Reactome,STRINGDB
AP1M1
Tbio
Novelty: 0.029282
Score: 0.999
Data Source: Reactome,STRINGDB
AP1B1
Tbio
Novelty: 0.03370208
Score: 0.998
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  30.52

PubMed score by year
PubTator Score  25.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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