Tbio AP1G1 AP-1 complex subunit gamma-1

Protein Summary

Description

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43747
• O75709
• O75842
• Q9UG09
• Q9Y3U4

Gene Name

• AP1G1

Ensembl ID

• ENST00000299980
• ENSP00000299980
• ENSG00000166747
• ENST00000393512
• ENSP00000377148
• ENST00000569748
• ENSP00000454523

Symbol

• ADTG
• CLAPG1
• ADTG
• CLAPG1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
transcription factor perturbation	0.94
protein domain	0.92
transcription factor binding site profile	0.89
disease perturbation	0.87

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Ap-1 Complex Subunit Gamma-1

DTO Classes

Protein / Receptor / Ap-1 Complex Subunit Gamma-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.69   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 223   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.69   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 223   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0