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Tbio
CHP2
Calcineurin B homologous protein 2

Protein Summary
Description
Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus. This gene product is a small calcium-binding protein that regulates cell pH by controlling plasma membrane-type Na+/H+ exchange activity. This protein shares sequence similarity with calcineurin B and can bind to and stimulate the protein phosphatase activity of calcineurin A (CnA) and functions in the calcineurin/NFAT (nuclear factor of activated T cells) signaling pathway. Another member of the CHP subfamily, Calcineurin B homo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300113
  • ENSP00000300113
  • ENSG00000166869

Symbol
  • HCA520
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.76
gene perturbation
0.59
cell line
0.48
microRNA
0.48
tissue
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.83   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.83   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Alzheimers Disease
WikiPathways
Alzheimers Disease
WikiPathways
Alzheimers Disease
WikiPathways
Alzheimers Disease
WikiPathways
G Protein Signaling Pathways
Name
Explore in Pharos
Explore in Source
Alzheimers Disease
Alzheimers Disease
Alzheimers Disease
Alzheimers Disease
G Protein Signaling Pathways
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (15)
1 – 10 of 15
SLC9A1
Tchem
Family: Transporter
Novelty: 0.00112175
Score: 0.939
Data Source: STRINGDB
C9orf78
Tdark
Novelty: 0.87993554
Score: 0.597
Data Source: STRINGDB
SLC9A3
Tclin
Family: Transporter
Novelty: 0.00164753
Score: 0.565
Data Source: STRINGDB
SLC9A5
Tchem
Family: Transporter
Novelty: 0.0667815
Score: 0.537
Data Source: STRINGDB
SLC9A2
Tchem
Family: Transporter
Novelty: 0.00790338
Score: 0.537
Data Source: STRINGDB
SLC9A4
Tdark
Family: Transporter
Novelty: 0.03974011
Score: 0.537
Data Source: STRINGDB
PPP3CC
Tbio
Family: Enzyme
Novelty: 0.04180044
Score: 0.514
Data Source: STRINGDB
PPP3CB
Tbio
Family: Enzyme
Novelty: 0.02520885
Score: 0.514
Data Source: STRINGDB
PPP3CA
Tchem
Family: Enzyme
Novelty: 0.00238194
Score: 0.514
Data Source: STRINGDB
MAGEC2
Tbio
Novelty: 0.00896194
Score: 0.477
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.83

PubMed score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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