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Tchem
PRKAB2
5'-AMP-activated protein kinase subunit beta-2

Protein Summary
Description
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254101
  • ENSP00000254101
  • ENSG00000131791
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
virus perturbation
0.94
transcription factor binding site profile
0.92
transcription factor perturbation
0.88
interacting protein
0.86


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.24   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.24   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
1
1
1
12.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
1
12.8
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein kinase AMP-activated non-catalytic subunit beta 2
VGNC:11802
457245
Horse
protein kinase AMP-activated non-catalytic subunit beta 2
VGNC:21837
100034095
Cow
protein kinase AMP-activated non-catalytic subunit beta 2
VGNC:33320
512665
Pig
protein kinase AMP-activated non-catalytic subunit beta 2
100157793
Opossum
protein kinase AMP-activated non-catalytic subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:9379]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein kinase AMP-activated non-catalytic subunit beta 2
Horse
protein kinase AMP-activated non-catalytic subunit beta 2
Cow
protein kinase AMP-activated non-catalytic subunit beta 2
Pig
protein kinase AMP-activated non-catalytic subunit beta 2
Opossum
protein kinase AMP-activated non-catalytic subunit beta 2 [Source:HGNC Symbol;Acc:HGNC:9379]
Protein Structure (13 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43741-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (70)
AMPK inhibits chREBP transcriptional activation activity (R-HSA-163680)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMPK inhibits chREBP transcriptional activation activity
Reactome
Activation of AMPK downstream of NMDARs
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Reactome
Autophagy
Name
Explore in Pharos
Explore in Source
AMPK inhibits chREBP transcriptional activation activity
Activation of AMPK downstream of NMDARs
Activation of NMDA receptors and postsynaptic events
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Autophagy
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (152)
1 – 10 of 152
PRKAG2
Tchem
Family:  Enzyme
Novelty:  0.00741608
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PRKAG1
Tchem
Family:  Kinase
Novelty:  0.07735301
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
STBD1
Tbio
Novelty:  0.08362185
p_int:  0.999999883
p_ni:  1.17e-7
Score:  0.735
Data Source:  BioPlex,STRINGDB
PRKAA1
Tclin
Family:  Kinase
Novelty:  0.01205826
p_int:  0.999999711
p_ni:  2.89e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PRKAG3
Tbio
Family:  Enzyme
Novelty:  0.01865144
p_int:  0.999999238
p_ni:  7.62e-7
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
PRKAA2
Tchem
Family:  Kinase
Novelty:  0.01795523
p_int:  0.999999213
p_ni:  7.87e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
DCLRE1C
Tbio
Novelty:  0.01064408
p_int:  0.999974159
p_ni:  0.000025545
p_wrong:  2.96e-7
Score:  0.699
Data Source:  BioPlex,STRINGDB
PRKAB1
Tchem
Family:  Kinase
Novelty:  0.01610606
p_int:  0.999511883
p_ni:  0.000001124
p_wrong:  0.000486993
Score:  0.982
Data Source:  BioPlex,STRINGDB
MID1IP1
Tbio
Novelty:  0.11443752
p_int:  0.999443258
p_ni:  0.00055627
p_wrong:  4.72e-7
Data Source:  BioPlex
NEB
Tbio
Novelty:  0.00174728
p_int:  0.999179052
p_ni:  0.000061601
p_wrong:  0.000759347
Score:  0.269
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  28.24

PubMed score by year
PubTator Score  5.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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