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Tchem
PRKAB2
5'-AMP-activated protein kinase subunit beta-2

Protein Summary
Description
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254101
  • ENSP00000254101
  • ENSG00000131791
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
virus perturbation
0.94
transcription factor binding site profile
0.92
transcription factor perturbation
0.88
interacting protein
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.78   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.78   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
MT47-100
chemical structure image
Protein Data Bank (13)
1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (70)
AMPK inhibits chREBP transcriptional activation activity (R-HSA-163680)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMPK inhibits chREBP transcriptional activation activity
Reactome
Activation of AMPK downstream of NMDARs
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Reactome
Autophagy
Name
Explore in Pharos
Explore in Source
AMPK inhibits chREBP transcriptional activation activity
Activation of AMPK downstream of NMDARs
Activation of NMDA receptors and postsynaptic events
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Autophagy
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (152)
1 – 10 of 152
PRKAG2
Tbio
Family: Enzyme
Novelty: 0.00943315
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PRKAG1
Tbio
Family: Kinase
Novelty: 0.1139086
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
STBD1
Tbio
Novelty: 0.12096774
p_int: 0.999999883
p_ni: 1.17e-7
Score: 0.735
Data Source: BioPlex,STRINGDB
PRKAA1
Tclin
Family: Kinase
Novelty: 0.01012358
p_int: 0.999999711
p_ni: 2.89e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PRKAG3
Tbio
Family: Enzyme
Novelty: 0.02150539
p_int: 0.999999238
p_ni: 7.62e-7
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
PRKAA2
Tchem
Family: Kinase
Novelty: 0.03339241
p_int: 0.999999213
p_ni: 7.87e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
DCLRE1C
Tbio
Novelty: 0.00510592
p_int: 0.999974159
p_ni: 0.000025545
p_wrong: 2.96e-7
Score: 0.699
Data Source: BioPlex,STRINGDB
PRKAB1
Tchem
Family: Kinase
Novelty: 0.027886
p_int: 0.999511883
p_ni: 0.000001124
p_wrong: 0.000486993
Score: 0.982
Data Source: BioPlex,STRINGDB
MID1IP1
Tbio
Novelty: 0.16023307
p_int: 0.999443258
p_ni: 0.00055627
p_wrong: 4.72e-7
Data Source: BioPlex
NEB
Tbio
Novelty: 0.00316169
p_int: 0.999179052
p_ni: 0.000061601
p_wrong: 0.000759347
Score: 0.269
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  14.78

PubMed score by year
PubTator Score  5.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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