Protein Summary
Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Play a role in the epithelial polarization (By similarity). This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in ad ...more
- ENST00000350796
- ENSP00000297044
- ENSG00000008256
- ENST00000396741
- ENSP00000379967
- ARNO3
- GRP1
- PSCD3
- GRP1
- ARNO3
- PSCD3
- cytohesin-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor binding site profile | 0.77 | ||
transcription factor | 0.73 | ||
cell type or tissue | 0.65 | ||
histone modification site profile | 0.62 | ||
kinase perturbation | 0.6 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 108.96 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 181 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 108.96 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 181 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (67)
CNKSR1
Family: Enzyme
Novelty: 0.06710697
p_int: 0.999999975
p_ni: 2.3e-8
p_wrong: 2e-9
Score: 0.544
Data Source: BioPlex,STRINGDB
IPCEF1
Novelty: 0.3372832
p_int: 0.999999937
p_ni: 6.2e-8
p_wrong: 1e-9
Score: 0.331
Data Source: BioPlex,STRINGDB
CYTIP
Novelty: 0.01965202
p_int: 0.999999678
p_ni: 3.21e-7
p_wrong: 1e-9
Score: 0.782
Data Source: BioPlex,STRINGDB
CCDC120
Novelty: 0.48574876
p_int: 0.999972135
p_ni: 0.000027865
Score: 0.275
Data Source: BioPlex,STRINGDB
INAVA
Novelty: 0.19311978
p_int: 0.999970809
p_ni: 0.000029182
p_wrong: 9e-9
Score: 0.316
Data Source: BioPlex,STRINGDB
FOSL2
Family: TF
Novelty: 0.00375452
p_int: 0.997913085
p_ni: 0.002086806
p_wrong: 1.1e-7
Score: 0.172
Data Source: BioPlex,STRINGDB
GPS2
Novelty: 0.00986158
p_int: 0.997123819
p_ni: 0.002851827
p_wrong: 0.000024355
Data Source: BioPlex
IFI35
Novelty: 0.04309126
p_int: 0.895699573
p_ni: 0.104300426
p_wrong: 1e-9
Score: 0.211
Data Source: BioPlex,STRINGDB
OIP5
Novelty: 0.02546471
p_int: 0.78681796
p_ni: 0.213141263
p_wrong: 0.000040777
Score: 0.193
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (77)
Reactome (4)
KEGG (2)
PathwayCommons (2)
WikiPathways (69)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Intra-Golgi and retrograde Golgi-to-ER traffic | ||||
Reactome | Intra-Golgi traffic | ||||
Reactome | Membrane Trafficking | ||||
Reactome | Vesicle-mediated transport | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Intra-Golgi and retrograde Golgi-to-ER traffic | ||||
Intra-Golgi traffic | ||||
Membrane Trafficking | ||||
Vesicle-mediated transport | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (2)
Components (8)
Processes (4)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 62.6 | |||||
neutrophil percentage of leukocytes | 1 | 1 | 1 | 42.3 | |||||
reticulocyte measurement | 1 | 1 | 1 | 31.1 | |||||
C-reactive protein measurement | 1 | 1 | 1 | 5.2 | |||||
Agents acting on the renin-angiotensin system use measurement | 1 | 1 | 1 | 4.7 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
lymphocyte percentage of leukocytes | 1 | 62.6 | |||||
neutrophil percentage of leukocytes | 1 | 42.3 | |||||
reticulocyte measurement | 1 | 31.1 | |||||
C-reactive protein measurement | 1 | 5.2 | |||||
Agents acting on the renin-angiotensin system use measurement | 1 | 4.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cytohesin 3 | VGNC:13643 | 100614767 | |||||
Macaque | cytohesin 3 | 717713 | ||||||
Mouse | MGI:1335107 | 19159 | ||||||
Rat | RGD:620399 | 116693 | ||||||
Horse | cytohesin 3 | VGNC:51122 | 100061994 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cytohesin 3 | |||||
Macaque | cytohesin 3 | |||||
Mouse | ||||||
Rat | ||||||
Horse | cytohesin 3 | |||||
Publication Statistics
PubMed Score 108.96
PubMed score by year
PubTator Score 57.79
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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