Tbio CYTH3 Cytohesin-3

Protein Summary

Description

Promotes guanine-nucleotide exchange on ARF1 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. Play a role in the epithelial polarization (By similarity). This gene encodes a member of the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. PSCD family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43739
• A4D2N8

Gene Name

• CYTH3

Ensembl ID

• ENST00000350796
• ENSP00000297044
• ENSG00000008256
• ENST00000396741
• ENSP00000379967

Symbol

• ARNO3
• GRP1
• PSCD3
• GRP1
• ARNO3
• PSCD3
• cytohesin-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.77
transcription factor	0.73
cell type or tissue	0.65
histone modification site profile	0.62
kinase perturbation	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.96   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 181   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.96   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (67)

Explore Interacting Targets

1 – 10 of 67

• See Interactions on String-DB

CNKSR1

Tchem

Family:  Enzyme

Novelty:  0.06710697

p_int:  0.999999975

p_ni:  2.3e-8

p_wrong:  2e-9

Score:  0.544

Data Source:  BioPlex,STRINGDB

IPCEF1

Tbio

Novelty:  0.3372832

p_int:  0.999999937

p_ni:  6.2e-8

p_wrong:  1e-9

Score:  0.331

Data Source:  BioPlex,STRINGDB

CYTIP

Tbio

Novelty:  0.01965202

p_int:  0.999999678

p_ni:  3.21e-7

p_wrong:  1e-9

Score:  0.782

Data Source:  BioPlex,STRINGDB

CCDC120

Tbio

Novelty:  0.48574876

p_int:  0.999972135

p_ni:  0.000027865

Score:  0.275

Data Source:  BioPlex,STRINGDB

INAVA

Tbio

Novelty:  0.19311978

p_int:  0.999970809

p_ni:  0.000029182

p_wrong:  9e-9

Score:  0.316

Data Source:  BioPlex,STRINGDB

SYCE1

Tbio

Novelty:  0.05038876

p_int:  0.999883435

p_ni:  0.000116565

Data Source:  BioPlex

FOSL2

Tbio

Family:  TF

Novelty:  0.00375452

p_int:  0.997913085

p_ni:  0.002086806

p_wrong:  1.1e-7

Score:  0.172

Data Source:  BioPlex,STRINGDB

GPS2

Tbio

Novelty:  0.00986158

p_int:  0.997123819

p_ni:  0.002851827

p_wrong:  0.000024355

Data Source:  BioPlex

IFI35

Tbio

Novelty:  0.04309126

p_int:  0.895699573

p_ni:  0.104300426

p_wrong:  1e-9

Score:  0.211

Data Source:  BioPlex,STRINGDB

OIP5

Tbio

Novelty:  0.02546471

p_int:  0.78681796

p_ni:  0.213141263

p_wrong:  0.000040777

Score:  0.193

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (77)

Reactome (4)

KEGG (2)

PathwayCommons (2)

WikiPathways (69)

Intra-Golgi and retrograde Golgi-to-ER traffic (R-HSA-6811442)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Intra-Golgi and retrograde Golgi-to-ER traffic	187 targets	R-HSA-6811442
Reactome	Intra-Golgi traffic	45 targets	R-HSA-6811438
Reactome	Membrane Trafficking	612 targets	R-HSA-199991
Reactome	Vesicle-mediated transport	725 targets	R-HSA-5653656

Name	Explore in Pharos	Explore in Source
Intra-Golgi and retrograde Golgi-to-ER traffic	187 targets	R-HSA-6811442
Intra-Golgi traffic	45 targets	R-HSA-6811438
Membrane Trafficking	612 targets	R-HSA-199991
Vesicle-mediated transport	725 targets	R-HSA-5653656

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (2)

Components (8)

Processes (4)

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Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
ARF guanyl-nucleotide exchange factor activity	Inferred from Direct Assay (IDA)	UniProtKB
phosphatidylinositol-3,4,5-trisphosphate binding	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte percentage of leukocytes	EFO_0007993	1	1	1		62.6
neutrophil percentage of leukocytes	EFO_0007990	1	1	1		42.3
reticulocyte measurement	EFO_0010700	1	1	1		31.1
C-reactive protein measurement	EFO_0004458	1	1	1		5.2
Agents acting on the renin-angiotensin system use measurement	EFO_0009931	1	1	1		4.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
lymphocyte percentage of leukocytes	EFO_0007993	1		62.6
neutrophil percentage of leukocytes	EFO_0007990	1		42.3
reticulocyte measurement	EFO_0010700	1		31.1
C-reactive protein measurement	EFO_0004458	1		5.2
Agents acting on the renin-angiotensin system use measurement	EFO_0009931	1		4.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell junction
Cell membrane
Coiled coil
Complete proteome
Cytoplasm
Guanine-nucleotide releasing factor
Lipid-binding
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
Agents acting on the renin-angiotensin system use measurement
C-reactive protein measurement
lymphocyte percentage of leukocytes
neutrophil percentage of leukocytes
reticulocyte measurement

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	cytohesin 3	VGNC:13643	100614767
Macaque	cytohesin 3		717713
Mouse	cytohesin 3	MGI:1335107	19159
Rat	cytohesin 3	RGD:620399	116693
Horse	cytohesin 3	VGNC:51122	100061994

Species	Name	OMA	EggNOG	Inparanoid
Chimp	cytohesin 3
Macaque	cytohesin 3
Mouse	cytohesin 3
Rat	cytohesin 3
Horse	cytohesin 3

Publication Statistics

PubMed Score 108.96

PubMed score by year

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PubTator Score 57.79

PubTator score by year

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Related Publications

Text Mined References (19)

GeneRif Annotations (4)

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10

0 of 0

PMID	Year	Title