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Tdark
KDELR3
ER lumen protein-retaining receptor 3

Protein Summary
Description
Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L (By similarity). This gene encodes a member of the KDEL endoplasmic reticulum protein retention receptor family. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 g ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000216014
  • ENSP00000216014
  • ENSG00000100196
  • ENST00000409006
  • ENSP00000386918

Symbol
  • ERD2L3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
kinase perturbation
0.97
PubMedID
0.94
histone modification site profile
0.74
small molecule perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.68   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.68   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gallstones
1
1
0
1.1
49.9
triglyceride measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gallstones
0
1.1
49.9
triglyceride measurement
1
40.7
Pathways (15)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Golgi-to-ER retrograde transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
ER to Golgi Anterograde Transport
Golgi-to-ER retrograde transport
Gene Ontology Terms (13)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (197)
1 – 10 of 197
TMEM56
Tdark
Novelty: 0.75633366
p_int: 0.999213263
p_ni: 0.000539829
p_wrong: 0.000246908
Score: 0.359
Data Source: BioPlex,STRINGDB
ALG8
Tbio
Family: Enzyme
Novelty: 0.03721075
p_int: 0.969810618
p_ni: 0.028486406
p_wrong: 0.001702976
Score: 0.154
Data Source: BioPlex,STRINGDB
SLC22A9
Tbio
Family: Transporter
Novelty: 0.02212992
p_int: 0.943388123
p_ni: 0.049603462
p_wrong: 0.007008415
Data Source: BioPlex
LPCAT3
Tbio
Family: Enzyme
Novelty: 0.00485213
p_int: 0.934364639
p_ni: 0.065635351
p_wrong: 1e-8
Score: 0.195
Data Source: BioPlex,STRINGDB
SLC4A2
Tbio
Family: Transporter
Novelty: 0.02448062
p_int: 0.933188239
p_ni: 0.066811761
Score: 0.181
Data Source: BioPlex,STRINGDB
DPEP2
Tbio
Family: Enzyme
Novelty: 0.14691384
p_int: 0.931557903
p_ni: 0.048512843
p_wrong: 0.019929254
Data Source: BioPlex
SYP
Tbio
Novelty: 0.00021543
p_int: 0.908489336
p_ni: 0.072045344
p_wrong: 0.019465321
Data Source: BioPlex
TMEM171
Tdark
Novelty: 2.00247773
p_int: 0.905162666
p_ni: 0.080326612
p_wrong: 0.014510722
Score: 0.165
Data Source: BioPlex,STRINGDB
LPAR6
Tchem
Family: GPCR
Novelty: 0.01801122
p_int: 0.889552396
p_ni: 0.102681962
p_wrong: 0.007765641
Data Source: BioPlex
VSIG4
Tbio
Novelty: 0.01671671
p_int: 0.862906797
p_ni: 0.008877092
p_wrong: 0.128216111
Data Source: BioPlex
Publication Statistics
PubMed Score  2.68

PubMed score by year
PubTator Score  0.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer