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Tbio
HTATSF1
HIV Tat-specific factor 1

Protein Summary
Description
Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Sep 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000218364
  • ENSP00000218364
  • ENSG00000102241
  • ENST00000535601
  • ENSP00000442699

Symbol
  • TATSF1
  • TAT-SF1
  • dJ196E23.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
interacting protein
0.98
virus perturbation
0.88
transcription factor perturbation
0.84
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.03   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.03   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (127)
1 – 10 of 127
PHF5A
Tbio
Family: Epigenetic
Novelty: 0.00307327
p_int: 0.999735846
p_ni: 0.000264154
Score: 0.574
Data Source: BioPlex,STRINGDB
SNRPA1
Tbio
Novelty: 0.02038744
p_int: 0.999680899
p_ni: 0.000319101
Score: 0.919
Data Source: BioPlex,STRINGDB
SNRPE
Tbio
Novelty: 0.00150118
p_int: 0.999606481
p_ni: 0.000393519
Score: 0.786
Data Source: BioPlex,STRINGDB
SNRPB2
Tdark
Novelty: 0.29045643
p_int: 0.998867889
p_ni: 0.001132111
Score: 0.721
Data Source: BioPlex,STRINGDB
SNRPN
Tbio
Novelty: 0.00241221
p_int: 0.997943347
p_ni: 0.002056653
Score: 0.781
Data Source: BioPlex,STRINGDB
SNRPB
Tbio
Novelty: 0.01137048
p_int: 0.995080523
p_ni: 0.004919477
Score: 0.596
Data Source: BioPlex,STRINGDB
SNRPGP15
Tdark
p_int: 0.994908389
p_ni: 0.005091611
Data Source: BioPlex
SNRPF
Tdark
Novelty: 0.22699635
p_int: 0.972904568
p_ni: 0.027095432
Score: 0.533
Data Source: BioPlex,STRINGDB
RBM7
Tbio
Novelty: 0.10889292
p_int: 0.949525237
p_ni: 0.050474763
Score: 0.209
Data Source: BioPlex,STRINGDB
TCEANC2
Tdark
Novelty: 0.49942499
p_int: 0.917079062
p_ni: 0.082920938
Score: 0.284
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  15.03

PubMed score by year
PubTator Score  13.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer