Tbio HTATSF1 HIV Tat-specific factor 1

Protein Summary

Description

Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Sep 2009]

Uniprot Accession IDs

• O43719
• D3DWG9
• Q59G06
• Q99730
• Tat-SF1

Gene Name

• HTATSF1

Ensembl ID

• ENST00000218364
• ENSP00000218364
• ENSG00000102241
• ENST00000535601
• ENSP00000442699

Symbol

• TATSF1
• TAT-SF1
• dJ196E23.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug perturbation	1
interacting protein	0.98
virus perturbation	0.88
transcription factor perturbation	0.84
ligand (protein) perturbation	0.83

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Hiv Tat-specific Factor 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Mrna Processing Factor / Mrna Splicing Factor / Hiv Tat-specific Factor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.37   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 256   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.37   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0