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Tbio
TRIAP1
TP53-regulated inhibitor of apoptosis 1

Protein Summary
Description
Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane (PubMed:23931759). Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) (PubMed:26071602). Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis (PubMed:15735003).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000546954
  • ENSP00000449795
  • ENSG00000170855

Symbol
  • 15E1.1
  • WF-1
  • MDM35
  • P53CSV
  • HSPC132
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
biological process
0.97
kinase perturbation
0.96
histone modification site profile
0.92
transcription factor binding site profile
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.66   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.66   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
1
1
48
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
1
48
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TP53 regulated inhibitor of apoptosis 1
VGNC:5638
742486
Mouse
MGI:1916326
69076
Dog
TP53 regulated inhibitor of apoptosis 1
VGNC:47800
489217
Horse
TP53 regulated inhibitor of apoptosis 1
VGNC:24491
100050391
Cow
TP53 regulated inhibitor of apoptosis 1
VGNC:36307
525164
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TP53 regulated inhibitor of apoptosis 1
Mouse
Dog
TP53 regulated inhibitor of apoptosis 1
Horse
TP53 regulated inhibitor of apoptosis 1
Cow
TP53 regulated inhibitor of apoptosis 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43715-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (8)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Transcription of Cell Death Genes
Reactome
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Transcription of Cell Death Genes
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Gene Ontology Terms (19)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (61)
1 – 10 of 61
PRELID1
Tbio
Novelty: 0.05605197
p_int: 1
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
PRELID3B
Tdark
Novelty: 0.2821617
p_int: 1
Score: 0.932
Data Source: BioPlex,STRINGDB
PRELID3A
Tbio
Novelty: 1.54594896
p_int: 0.999974579
p_ni: 1e-9
p_wrong: 0.00002542
Score: 0.992
Data Source: BioPlex,STRINGDB
JCHAIN
Tbio
Novelty: 0.00172454
p_int: 0.942669583
p_ni: 0.015671252
p_wrong: 0.041659165
Score: 0.243
Data Source: BioPlex,STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.963
Data Source: STRINGDB
COX19
Tbio
Family: Enzyme
Novelty: 0.06540633
Score: 0.761
Data Source: STRINGDB
SNRPG
Tbio
Novelty: 0.1684808
Score: 0.706
Data Source: STRINGDB
TAMM41
Tbio
Family: Enzyme
Novelty: 0.06004824
Score: 0.7
Data Source: STRINGDB
COX17
Tbio
Family: Enzyme
Novelty: 0.01025112
Score: 0.698
Data Source: STRINGDB
UBL5
Tbio
Novelty: 0.07594149
Score: 0.676
Data Source: STRINGDB
Publication Statistics
PubMed Score  138.66

PubMed score by year
PubTator Score  21.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer