TLX3
T-cell leukemia homeobox protein 3
Protein Summary
The protein encoded by this gene is an orphan homeobox protein that encodes a DNA-binding nuclear transcription factor. A translocation [t(5;14)(q35;q32)] involving this gene is associated with T-cell acute lymphoblastic leukemia (T-ALL) in children and young adults. [provided by RefSeq, Nov 2015]
- ENST00000296921
- ENSP00000296921
- ENSG00000164438
- HOX11L2
- RNX
- HOX11L2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.82 | ||
transcription factor | 0.63 | ||
PubMedID | 0.62 | ||
protein domain | 0.58 | ||
transcription factor binding site profile | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 89.19 (req: < 5)
Gene RIFs: 21 (req: <= 3)
Antibodies: 141 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 89.19 (req: >= 5)
Gene RIFs: 21 (req: > 3)
Antibodies: 141 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (52)
Nearest Tclin Targets
Pathways (4)
KEGG (1)
WikiPathways (3)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Transcriptional misregulation in cancer | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Transcriptional misregulation in cancer | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (2)
Components (1)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
comparative body size at age 10, self-reported | 1 | 1 | 1 | 42.3 | |||||
mathematical ability | 1 | 1 | 1 | 21.5 | |||||
1 | 1 | 1 | 21.5 | ||||||
cortical surface area measurement | 1 | 1 | 0 | 516.5 | 8.6 | ||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
comparative body size at age 10, self-reported | 1 | 42.3 | |||||
mathematical ability | 1 | 21.5 | |||||
1 | 21.5 | ||||||
cortical surface area measurement | 0 | 516.5 | 8.6 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:1351209 | 27140 | ||||||
Rat | RGD:1564190 | 497881 | ||||||
Dog | T-cell leukemia homeobox 3 | 489123 | ||||||
Horse | T-cell leukemia homeobox 3 | 100059154 | ||||||
Cow | T-cell leukemia homeobox 3 | 618473 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | T-cell leukemia homeobox 3 | |||||
Horse | T-cell leukemia homeobox 3 | |||||
Cow | T-cell leukemia homeobox 3 | |||||
Publication Statistics
PubMed Score 89.19
PubMed score by year
PubTator Score 43.76
PubTator score by year
Related Publications
Text Mined References (29)
GeneRif Annotations (21)
Items per page:
0 of 0
PMID | Year | Title |
|---|