Tbio TLX3 T-cell leukemia homeobox protein 3

Protein Summary

Description

The protein encoded by this gene is an orphan homeobox protein that encodes a DNA-binding nuclear transcription factor. A translocation [t(5;14)(q35;q32)] involving this gene is associated with T-cell acute lymphoblastic leukemia (T-ALL) in children and young adults. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• O43711
• Q96AD3

Gene Name

• TLX3

Ensembl ID

• ENST00000296921
• ENSP00000296921
• ENSG00000164438

Symbol

• HOX11L2
• RNX
• HOX11L2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.82
transcription factor	0.63
PubMedID	0.62
protein domain	0.58
transcription factor binding site profile	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.09   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 141   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112.09   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0