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Tbio
ACTN4
Alpha-actinin-4

Protein Summary
Description
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252699
  • ENSP00000252699
  • ENSG00000130402
  • ENST00000390009
  • ENSP00000439497
  • ENST00000634692
  • ENSP00000488962
  • ENSG00000282844
  • ENST00000634960
  • ENSP00000489220

Symbol
  • FSGS
  • FSGS1
  • ACTININ-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.99
protein domain
0.99
molecular function
0.98
cellular component
0.91


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 260.24   (req: < 5)
Gene RIFs: 101   (req: <= 3)
Antibodies: 398   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 260.24   (req: >= 5)
Gene RIFs: 101   (req: > 3)
Antibodies: 398   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
retinal vasculature measurement
1
1
1
68.6
retinal vasculature measurement
1
1
1
68.6
platelet count
1
1
1
41.8
platelet count
1
1
1
41.8
mean platelet volume
1
1
1
32.6
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
retinal vasculature measurement
1
68.6
retinal vasculature measurement
1
68.6
platelet count
1
41.8
platelet count
1
41.8
mean platelet volume
1
32.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
actinin alpha 4
VGNC:6604
456010
Macaque
actinin alpha 4
693666
Mouse
MGI:1890773
60595
Rat
RGD:61816
63836
Dog
actinin alpha 4
VGNC:37550
484526
Species
Name
OMA
EggNOG
Inparanoid
Chimp
actinin alpha 4
Macaque
actinin alpha 4
Mouse
Rat
Dog
actinin alpha 4
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (23)
Cell-Cell communication (R-HSA-1500931)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell-Cell communication
Reactome
Hemostasis
Reactome
Nephrin family interactions
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Name
Explore in Pharos
Explore in Source
Cell-Cell communication
Hemostasis
Nephrin family interactions
Platelet activation, signaling and aggregation
Platelet degranulation
Gene Ontology Terms (54)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (292)
1 – 10 of 292
PDLIM1
Tbio
Novelty: 0.02703639
p_int: 0.92728941
p_ni: 0.07271059
Score: 0.764
Data Source: BioPlex,STRINGDB
ACTN1
Tbio
Novelty: 0.00654004
Score: 0.999
Data Source: STRINGDB
ACTN2
Tbio
Novelty: 0.00615882
Score: 0.998
Data Source: STRINGDB
VCL
Tbio
Novelty: 0.00043107
Score: 0.998
Data Source: STRINGDB
ACTN3
Tbio
Novelty: 0.00375035
Score: 0.986
Data Source: STRINGDB
NPHS1
Tbio
Novelty: 0.00104742
Score: 0.98
Data Source: Reactome,STRINGDB
ITGB1
Tclin
Novelty: 0.00055626
Score: 0.97
Data Source: STRINGDB
KIRREL1
Tbio
Novelty: 0.03216031
Score: 0.967
Data Source: Reactome,STRINGDB
USP6NL
Tbio
Novelty: 0.09667588
Score: 0.964
Data Source: STRINGDB
ZYX
Tbio
Novelty: 0.00375452
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  260.24

PubMed score by year
PubTator Score  562.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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