Protein Summary
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal i ...more
- ENST00000252699
- ENSP00000252699
- ENSG00000130402
- ENST00000390009
- ENSP00000439497
- ENST00000634692
- ENSP00000488962
- ENSG00000282844
- ENST00000634960
- ENSP00000489220
- FSGS
- FSGS1
- ACTININ-4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
disease perturbation | 0.99 | ||
protein domain | 0.99 | ||
molecular function | 0.98 | ||
cellular component | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 266 (req: < 5)
Gene RIFs: 101 (req: <= 3)
Antibodies: 398 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 266 (req: >= 5)
Gene RIFs: 101 (req: > 3)
Antibodies: 398 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 34
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (292)
PDLIM1
Novelty: 0.02703639
p_int: 0.92728941
p_ni: 0.07271059
Score: 0.764
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (3)
Upstream (2)
Downstream (1)
1 – 2 of 2
Pathways (23)
Reactome (6)
KEGG (8)
PathwayCommons (4)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell-Cell communication | ||||
Reactome | Hemostasis | ||||
Reactome | Nephrin family interactions | ||||
Reactome | Platelet activation, signaling and aggregation | ||||
Reactome | Platelet degranulation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell-Cell communication | ||||
Hemostasis | ||||
Nephrin family interactions | ||||
Platelet activation, signaling and aggregation | ||||
Platelet degranulation | ||||
Viral Interactions (0)
Gene Ontology Terms (54)
Functions (15)
Components (20)
Processes (19)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
platelet count | 3 | 3 | 3 | 92.2 | ||||||
platelet count | 3 | 3 | 3 | 92.2 | ||||||
platelet crit | 1 | 1 | 1 | 66.8 | ||||||
platelet crit | 1 | 1 | 1 | 66.8 | ||||||
mean platelet volume | 1 | 1 | 1 | 62.1 | ||||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet count | 3 | 92.2 | |||||
platelet count | 3 | 92.2 | |||||
platelet crit | 1 | 66.8 | |||||
platelet crit | 1 | 66.8 | |||||
mean platelet volume | 1 | 62.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | actinin alpha 4 | VGNC:6604 | 456010 | |||||
Macaque | actinin alpha 4 | 693666 | ||||||
Mouse | MGI:1890773 | 60595 | ||||||
Rat | RGD:61816 | 63836 | ||||||
Dog | actinin alpha 4 | VGNC:37550 | 484526 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | actinin alpha 4 | |||||
Macaque | actinin alpha 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | actinin alpha 4 | |||||
Publication Statistics
PubMed Score 266.00
PubMed score by year
PubTator Score 562.20
PubTator score by year
Related Publications
Text Mined References (163)
GeneRif Annotations (101)
Items per page:
0 of 0
PMID | Year | Title |
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