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Tbio
ACTN4
Alpha-actinin-4

Protein Summary
Description
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (Probable). Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation (PubMed:15772161). Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions (By similarity). May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA (PubMed:22351778). Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal i ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252699
  • ENSP00000252699
  • ENSG00000130402
  • ENST00000390009
  • ENSP00000439497
  • ENST00000634692
  • ENSP00000488962
  • ENSG00000282844
  • ENST00000634960
  • ENSP00000489220

Symbol
  • FSGS
  • FSGS1
  • ACTININ-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.99
protein domain
0.99
molecular function
0.98
cellular component
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.99   (req: < 5)
Gene RIFs: 101   (req: <= 3)
Antibodies: 398   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.99   (req: >= 5)
Gene RIFs: 101   (req: > 3)
Antibodies: 398   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (23)
Cell-Cell communication (R-HSA-1500931)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell-Cell communication
Reactome
Hemostasis
Reactome
Nephrin family interactions
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Name
Explore in Pharos
Explore in Source
Cell-Cell communication
Hemostasis
Nephrin family interactions
Platelet activation, signaling and aggregation
Platelet degranulation
Gene Ontology Terms (54)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (292)
1 – 10 of 292
PDLIM1
Tbio
Novelty: 0.00702162
p_int: 0.92728941
p_ni: 0.07271059
Score: 0.764
Data Source: BioPlex,STRINGDB
ACTN1
Tbio
Novelty: 0.01041776
Score: 0.999
Data Source: STRINGDB
ACTN2
Tbio
Novelty: 0.00993205
Score: 0.998
Data Source: STRINGDB
VCL
Tbio
Novelty: 0.00044707
Score: 0.998
Data Source: STRINGDB
ACTN3
Tbio
Novelty: 0.00478226
Score: 0.986
Data Source: STRINGDB
NPHS1
Tbio
Novelty: 0.00130766
Score: 0.98
Data Source: Reactome,STRINGDB
ITGB1
Tclin
Novelty: 0.00074903
Score: 0.97
Data Source: STRINGDB
KIRREL1
Tbio
Novelty: 0.03852239
Score: 0.967
Data Source: Reactome,STRINGDB
USP6NL
Tbio
Novelty: 0.16106353
Score: 0.964
Data Source: STRINGDB
ZYX
Tbio
Novelty: 0.00647259
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  212.99

PubMed score by year
PubTator Score  562.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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