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Tbio
SULT1B1
Sulfotransferase family cytosolic 1B member 1

Protein Summary
Description
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine and thyroxine. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000310613
  • ENSP00000308770
  • ENSG00000173597

Symbol
  • ST1B2
  • SULT1B2
  • ST1B1
  • ST1B2
  • SULT1B2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
small molecule perturbation
0.73
disease perturbation
0.68
cell line
0.63
trait
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.99   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.99   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
56.6
heel bone mineral density
2
1
2
42.3
sex hormone-binding globulin measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
56.6
heel bone mineral density
2
42.3
sex hormone-binding globulin measurement
1
24.5
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sulfotransferase family 1B member 1
VGNC:12845
471216
Macaque
sulfotransferase family 1B member 1
708638
Mouse
MGI:2136282
56362
Rat
RGD:708534
64305
Dog
sulfotransferase family 1B member 1
VGNC:46976
403636
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sulfotransferase family 1B member 1
Macaque
sulfotransferase family 1B member 1
Mouse
Rat
Dog
sulfotransferase family 1B member 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43704-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytosolic sulfonation of small molecules
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytosolic sulfonation of small molecules
Metabolism
Phase II - Conjugation of compounds
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (21)
1 – 10 of 21
SULT2A1
Tbio
Family:  Enzyme
Novelty:  0.00475549
Score:  0.618
Data Source:  STRINGDB
CHST10
Tbio
Family:  Enzyme
Novelty:  0.06829376
Score:  0.54
Data Source:  STRINGDB
UGT1A6
Tbio
Family:  Enzyme
Novelty:  0.00146917
Score:  0.533
Data Source:  STRINGDB
SULT2B1
Tbio
Family:  Enzyme
Novelty:  0.02652128
Score:  0.525
Data Source:  STRINGDB
UGT1A1
Tchem
Family:  Enzyme
Novelty:  0.00135044
Score:  0.518
Data Source:  STRINGDB
UGT1A8
Tbio
Family:  Enzyme
Novelty:  0.00135129
Score:  0.514
Data Source:  STRINGDB
ASGR1
Tbio
Novelty:  0.00209845
Score:  0.507
Data Source:  STRINGDB
SHROOM4
Tbio
Novelty:  0.21822165
Score:  0.48
Data Source:  STRINGDB
CYP3A5
Tclin
Family:  Enzyme
Novelty:  0.00105607
Score:  0.473
Data Source:  STRINGDB
PAPSS2
Tbio
Family:  Enzyme
Novelty:  0.01538798
Score:  0.465
Data Source:  STRINGDB
Publication Statistics
PubMed Score  33.99

PubMed score by year
PubTator Score  20.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer