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Tbio
SIGLEC6
Sialic acid-binding Ig-like lectin 6

Protein Summary
Description
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343300
  • ENSP00000345907
  • ENSG00000105492
  • ENST00000346477
  • ENSP00000344064
  • ENST00000359982
  • ENSP00000353071
  • ENST00000391797
  • ENSP00000375674
  • ENST00000425629
  • ENSP00000401502
  • ENST00000436458
  • ENSP00000410679

Symbol
  • CD33L
  • CD33L1
  • OBBP1
  • CD327
  • CD33L
  • OBBP1
  • CD33L1
  • CD33L2
  • CDW327
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
cell type or tissue
0.73
cell line
0.5
disease perturbation
0.49
small molecule perturbation
0.47


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.22   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 350   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.22   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 350   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (9)
PAPPA2
Tbio
Novelty:  0.02135603
Score:  0.632
Data Source:  STRINGDB
LEP
Tbio
Novelty:  0.00005295
Score:  0.603
Data Source:  STRINGDB
SLAMF1
Tbio
Novelty:  0.00112892
Score:  0.563
Data Source:  STRINGDB
PAEP
Tbio
Novelty:  0.00125851
Score:  0.531
Data Source:  STRINGDB
FCRL4
Tbio
Novelty:  0.03750876
Score:  0.502
Data Source:  STRINGDB
TCF4
Tbio
Family:  TF
Novelty:  0.0019718
Score:  0.497
Data Source:  STRINGDB
HTRA4
Tbio
Family:  Enzyme
Novelty:  0.09298487
Score:  0.441
Data Source:  STRINGDB
INHA
Tbio
Novelty:  0.00168407
Score:  0.414
Data Source:  STRINGDB
ZNF175
Tbio
Family:  TF
Novelty:  0.14954586
Score:  0.4
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
1
1
69.5
lymphocyte count
2
1
2
64.9
neutrophil percentage of leukocytes
1
1
1
59.5
eosinophil percentage of leukocytes
1
1
1
56.4
mean corpuscular volume
1
1
1
38.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
69.5
lymphocyte count
2
64.9
neutrophil percentage of leukocytes
1
59.5
eosinophil percentage of leukocytes
1
56.4
mean corpuscular volume
1
38.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sialic acid binding Ig like lectin 6
VGNC:2424
456250
Macaque
sialic acid binding Ig like lectin 6
719684
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sialic acid binding Ig like lectin 6
Macaque
sialic acid binding Ig like lectin 6
Publication Statistics
PubMed Score 16.22
PubMed score by year
PubTator Score 10.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title