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Tbio
SIGLEC6
Sialic acid-binding Ig-like lectin 6

Protein Summary
Description
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343300
  • ENSP00000345907
  • ENSG00000105492
  • ENST00000346477
  • ENSP00000344064
  • ENST00000359982
  • ENSP00000353071
  • ENST00000391797
  • ENSP00000375674
  • ENST00000425629
  • ENSP00000401502
  • ENST00000436458
  • ENSP00000410679

Symbol
  • CD33L
  • CD33L1
  • OBBP1
  • CD327
  • CD33L
  • OBBP1
  • CD33L1
  • CD33L2
  • CDW327
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
cell type or tissue
0.73
cell line
0.5
disease perturbation
0.49
small molecule perturbation
0.47


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.54   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 350   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.54   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 350   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0