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Tbio
PLPP2
Phospholipid phosphatase 2

Protein Summary
Description
Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P. The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269812
  • ENSP00000269812
  • ENSG00000141934
  • ENST00000327790
  • ENSP00000329697
  • ENST00000434325
  • ENSP00000388565

Symbol
  • LPP2
  • PPAP2C
  • LPP2
  • PAP-2c
  • PAP2-g
  • PPAP2C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.65   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.65   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (16)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Gene Ontology Terms (11)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (116)
1 – 10 of 116
MOGAT1
Tbio
Family: Enzyme
Novelty: 0.0503068
Score: 0.977
Data Source: STRINGDB
LPCAT3
Tbio
Family: Enzyme
Novelty: 0.00485213
Score: 0.958
Data Source: STRINGDB
SGPP2
Tbio
Family: Enzyme
Novelty: 0.09408823
Score: 0.954
Data Source: STRINGDB
SGPP1
Tbio
Family: Enzyme
Novelty: 0.0514048
Score: 0.947
Data Source: STRINGDB
CHPT1
Tbio
Family: Enzyme
Novelty: 0.02875977
Score: 0.942
Data Source: STRINGDB
DGAT2
Tchem
Family: Enzyme
Novelty: 0.00488581
Score: 0.941
Data Source: STRINGDB
SGPL1
Tchem
Family: Enzyme
Novelty: 0.00272574
Score: 0.941
Data Source: STRINGDB
AGPAT3
Tbio
Family: Enzyme
Novelty: 0.06139822
Score: 0.94
Data Source: STRINGDB
AGPAT1
Tbio
Family: Enzyme
Novelty: 0.05245441
Score: 0.937
Data Source: STRINGDB
AGPAT5
Tbio
Family: Enzyme
Novelty: 0.23785857
Score: 0.936
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.65

PubMed score by year
PubTator Score  9.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer