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Tbio
BUB3
Mitotic checkpoint protein BUB3

Protein Summary
Description
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368858
  • ENSP00000357851
  • ENSG00000154473
  • ENST00000368865
  • ENSP00000357858

Symbol
  • BUB3L
  • hBUB3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
interacting protein
1
virus perturbation
1
disease perturbation
0.99
transcription factor perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.59   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 338   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.59   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 338   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (372)
BUB1
Tchem
Family:  Kinase
Novelty:  0.00327514
p_int:  0.999999999
p_ni:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
BUB1B
Tbio
Family:  Kinase
Novelty:  0.00239073
p_int:  0.999999977
p_ni:  1.1e-8
p_wrong:  1.2e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ZFC3H1
Tbio
Novelty:  0.17313739
p_int:  0.999999854
p_ni:  1.46e-7
Score:  0.28
Data Source:  BioPlex,STRINGDB
KCTD20
Tdark
Novelty:  0.47655751
p_int:  0.99999965
p_ni:  1e-7
p_wrong:  2.5e-7
Score:  0.297
Data Source:  BioPlex,STRINGDB
BTBD10
Tbio
Novelty:  0.23077172
p_int:  0.99999857
p_ni:  0.000001105
p_wrong:  3.25e-7
Score:  0.527
Data Source:  BioPlex,STRINGDB
ZNF207
Tbio
Novelty:  0.09012794
p_int:  0.999972817
p_ni:  0.000027183
p_wrong:  1e-9
Score:  0.979
Data Source:  BioPlex,STRINGDB
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.997165428
p_ni:  0.002834572
Score:  0.198
Data Source:  BioPlex,STRINGDB
CDC27
Tbio
Novelty:  0.00589846
p_int:  0.992817907
p_ni:  0.00718203
p_wrong:  6.3e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
CCT4
Tbio
Novelty:  0.01176123
p_int:  0.982466121
p_ni:  0.017533879
Score:  0.396
Data Source:  BioPlex,STRINGDB
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.979199247
p_ni:  0.020800753
Score:  0.598
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (53)
APC-Cdc20 mediated degradation of Nek2A (R-HSA-179409)

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Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC-Cdc20 mediated degradation of Nek2A
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of mitotic proteins
Reactome
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Reactome
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Name
Explore in Pharos
Explore in Source
APC-Cdc20 mediated degradation of Nek2A
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of mitotic proteins
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep duration
1
1
1
6
body weights and measures
1
1
1
2.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sleep duration
1
6
body weights and measures
1
2.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
BUB3, mitotic checkpoint protein
708033
Mouse
MGI:1343463
12237
Dog
BUB3, mitotic checkpoint protein
VGNC:38567
477857
Horse
BUB3, mitotic checkpoint protein
VGNC:15926
100050269
Cow
BUB3, mitotic checkpoint protein
VGNC:26606
539594
Species
Name
OMA
EggNOG
Inparanoid
Macaque
BUB3, mitotic checkpoint protein
Mouse
Dog
BUB3, mitotic checkpoint protein
Horse
BUB3, mitotic checkpoint protein
Cow
BUB3, mitotic checkpoint protein
Publication Statistics
PubMed Score 121.59
PubMed score by year
PubTator Score 56.29
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title