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Tchem
BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

Protein Summary
Description
Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiq ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302759
  • ENSP00000302530
  • ENSG00000169679
  • ENST00000409311
  • ENSP00000386701
  • ENST00000535254
  • ENSP00000441013

Symbol
  • BUB1L
  • BUB1A
  • BUB1L
  • hBUB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.97
kinase perturbation
0.93
molecular function
0.91
small molecule perturbation
0.89
biological process
0.88


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 309.89   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 484   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 309.89   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 484   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BUB1 mitotic checkpoint serine/threonine kinase
VGNC:177
459484
Macaque
BUB1 mitotic checkpoint serine/threonine kinase
696598
Mouse
MGI:1100510
12235
Rat
RGD:1311707
296137
Dog
BUB1 mitotic checkpoint serine/threonine kinase
VGNC:38565
100682599
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BUB1 mitotic checkpoint serine/threonine kinase
Macaque
BUB1 mitotic checkpoint serine/threonine kinase
Mouse
Rat
Dog
BUB1 mitotic checkpoint serine/threonine kinase
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43683-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (52)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (19)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (429)
1 – 10 of 429
BUB3
Tbio
Novelty:  0.00714143
p_int:  0.999999999
p_ni:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
BUB1B
Tbio
Family:  Kinase
Novelty:  0.00239073
p_int:  0.999981491
p_ni:  0.000018509
Score:  0.999
Data Source:  BioPlex,STRINGDB
PRELID2
Tdark
Novelty:  0.38276284
p_int:  0.998917312
p_ni:  0.001058822
p_wrong:  0.000023866
Data Source:  BioPlex
CDC16
Tbio
Novelty:  0.00916715
p_int:  0.992782018
p_ni:  0.007217981
p_wrong:  1e-9
Score:  0.888
Data Source:  BioPlex,STRINGDB
NCAPH2
Tbio
Novelty:  0.12134933
p_int:  0.992325875
p_ni:  0.007674112
p_wrong:  1.4e-8
Score:  0.557
Data Source:  BioPlex,STRINGDB
MLF1
Tbio
Novelty:  0.0239522
p_int:  0.992235422
p_ni:  0.007764576
p_wrong:  2e-9
Score:  0.47
Data Source:  BioPlex,STRINGDB
RAE1
Tbio
Novelty:  0.01342883
p_int:  0.991893563
p_ni:  0.008106437
Score:  0.841
Data Source:  BioPlex,STRINGDB
KNL1
Tbio
Novelty:  0.01084826
p_int:  0.988573701
p_ni:  0.011426298
Score:  0.999
Data Source:  BioPlex,STRINGDB
BRINP3
Tbio
Novelty:  0.07870037
p_int:  0.979147223
p_ni:  0.020852543
p_wrong:  2.33e-7
Data Source:  BioPlex
DNA2
Tbio
Family:  Enzyme
Novelty:  0.00195682
p_int:  0.97911296
p_ni:  0.020886642
p_wrong:  3.98e-7
Score:  0.502
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  309.89

PubMed score by year
PubTator Score  162.95

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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