Tbio ASNA1 ATPase ASNA1

Protein Summary

Description

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling. This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• O43681
• A6NHP8
• A8K740
• Q53FC6
• Q92849

Gene Name

• ASNA1

Ensembl ID

• ENST00000357332
• ENSP00000349887
• ENSG00000198356
• ENST00000591090
• ENSP00000466379

Symbol

• ARSA
• TRC40
• GET3
• ARSA1
• TRC40
• ARSA-I
• ASNA-I

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
disease perturbation	0.83
cellular component	0.81
transcription factor binding site profile	0.68
tissue sample	0.64

Protein Classes

PANTHER Classes

Protein / Transporter / Atpase Asna1

Protein / Hydrolase / Phosphatase / Nucleotide Phosphatase / Atpase Asna1

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Nucleotide Phosphatase / Atpase Asna1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.12   (req: < 5)

Gene RIFs: 19   (req: <= 3)

Antibodies: 322   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.12   (req: >= 5)

Gene RIFs: 19   (req: > 3)

Antibodies: 322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0