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Tbio
ASNA1
ATPase ASNA1

Protein Summary
Description
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling. This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to ars ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357332
  • ENSP00000349887
  • ENSG00000198356
  • ENST00000591090
  • ENSP00000466379

Symbol
  • ARSA
  • TRC40
  • GET3
  • ARSA1
  • TRC40
  • ARSA-I
  • ASNA-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
disease perturbation
0.83
cellular component
0.81
transcription factor binding site profile
0.68
tissue sample
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.8   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 322   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.8   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
2
2
82.5
reticulocyte measurement
1
1
1
68.8
mean corpuscular volume
1
1
1
54.4
HbA1c measurement
1
1
1
44.2
cathepsin L1 measurement
1
1
1
42.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
2
82.5
reticulocyte measurement
1
68.8
mean corpuscular volume
1
54.4
HbA1c measurement
1
44.2
cathepsin L1 measurement
1
42.3
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
455750
Macaque
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
717734
Mouse
MGI:1928379
56495
Rat
RGD:1307906
288919
Dog
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
476699
Species
Name
OMA
EggNOG
Inparanoid
Chimp
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
Macaque
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
Mouse
Rat
Dog
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43681-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (R-HSA-9609523)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Protein localization
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (115)
1 – 10 of 115
CAMLG
Tbio
Novelty:  0.0088918
p_int:  0.999999524
p_ni:  4.76e-7
Score:  0.956
Data Source:  BioPlex,Reactome,STRINGDB
WRB
Tbio
Novelty:  0.01267171
p_int:  0.999498812
p_ni:  0.000501188
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
ZNF579
Tdark
Family:  TF
Novelty:  4.75515836
p_int:  0.998877026
p_ni:  0.001122972
p_wrong:  2e-9
Score:  0.199
Data Source:  BioPlex,STRINGDB
ASPSCR1
Tbio
Novelty:  0.01172319
p_int:  0.995198667
p_ni:  0.004801333
Score:  0.228
Data Source:  BioPlex,STRINGDB
NUDT9
Tbio
Family:  Enzyme
Novelty:  0.0482661
p_int:  0.985229287
p_ni:  0.014770712
p_wrong:  1e-9
Score:  0.283
Data Source:  BioPlex,STRINGDB
GET4
Tbio
Novelty:  0.03516005
Score:  0.998
Data Source:  Reactome,STRINGDB
SEC61A1
Tbio
Novelty:  0.0026034
Score:  0.986
Data Source:  STRINGDB
SEC62
Tbio
Novelty:  0.01236418
Score:  0.972
Data Source:  STRINGDB
SEC61B
Tbio
Novelty:  0.08622222
Score:  0.963
Data Source:  STRINGDB
SEC63
Tbio
Novelty:  0.00974614
Score:  0.957
Data Source:  STRINGDB
Publication Statistics
PubMed Score  106.80

PubMed score by year
PubTator Score  40.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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