TCF21
Transcription factor 21
Protein Summary
Involved in epithelial-mesenchymal interactions in kidney and lung morphogenesis that include epithelial differentiation and branching morphogenesis. May play a role in the specification or differentiation of one or more subsets of epicardial cell types. TCF21 encodes a transcription factor of the basic helix-loop-helix family. The TCF21 product is mesoderm specific, and expressed in embryonic epicardium, mesenchyme-derived tissues of lung, gut, gonad, and both mesenchymal and glomerular epithelial cells in the kidney. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000237316
- ENSP00000237316
- ENSG00000118526
- ENST00000367882
- ENSP00000356857
- BHLHA23
- POD1
- POD1
- bHLHa23
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.94 | ||
molecular function | 0.91 | ||
PubMedID | 0.87 | ||
gene perturbation | 0.8 | ||
tissue sample | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1796.34 (req: < 5)
Gene RIFs: 32 (req: <= 3)
Antibodies: 138 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1796.34 (req: >= 5)
Gene RIFs: 32 (req: > 3)
Antibodies: 138 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 34
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (71)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (35)
Functions (8)
Components (1)
Processes (26)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
9 | 4 | 4 | 1.1 | 96.6 | |||||
2 | 2 | 0 | 1.1 | 84.5 | |||||
hematocrit | 2 | 1 | 2 | 67.1 | |||||
hemoglobin measurement | 2 | 2 | 2 | 62.6 | |||||
creatinine measurement | 1 | 1 | 1 | 58.4 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
4 | 1.1 | 96.6 | |||||
0 | 1.1 | 84.5 | |||||
hematocrit | 2 | 67.1 | |||||
hemoglobin measurement | 2 | 62.6 | |||||
creatinine measurement | 1 | 58.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | transcription factor 21 | VGNC:3743 | 463151 | |||||
Macaque | transcription factor 21 | 707680 | ||||||
Mouse | MGI:1202715 | 21412 | ||||||
Rat | RGD:620523 | 252856 | ||||||
Dog | transcription factor 21 | VGNC:47193 | 483993 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | transcription factor 21 | |||||
Macaque | transcription factor 21 | |||||
Mouse | ||||||
Rat | ||||||
Dog | transcription factor 21 | |||||
Publication Statistics
PubMed Score 1796.34
PubMed score by year
PubTator Score 65.39
PubTator score by year
Related Publications
Text Mined References (49)
GeneRif Annotations (32)
Items per page:
0 of 0
PMID | Year | Title |
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