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Tclin
NDUFA2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

Protein Classes
Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The encoded protein is a subunit of the hydrophobic protein fraction of the NADH:ubiquinone oxidoreductase (complex 1), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane, and may be involved in regulating complex I activity or its assembly via assistance in redox processes. Mutations in this gene are associated with Leigh syndrome, an early-onset progressive neurodegenerative disorder. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252102
  • ENSP00000252102
  • ENSG00000131495
  • ENST00000512088
  • ENSP00000427220

Symbol
  • B8
  • CD14
  • CIB8
  • MC1DN13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
interacting protein
0.9
kinase perturbation
0.81
disease perturbation
0.74
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.53   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.53   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
Rendered image for metformin
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
3
1
5.9
56.4
self reported educational attainment
2
2
2
45.2
household income
1
1
1
24.5
cognitive function measurement
3
1
3
24.5
systolic blood pressure
1
1
1
24.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
5.9
56.4
self reported educational attainment
2
45.2
household income
1
24.5
cognitive function measurement
3
24.5
systolic blood pressure
1
24.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A2
VGNC:4095
462119
Mouse
MGI:1343103
17991
Rat
RGD:1309997
291660
Dog
NADH:ubiquinone oxidoreductase subunit A2
VGNC:43687
478032
Horse
NADH:ubiquinone oxidoreductase subunit A2
VGNC:20623
100061811
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit A2
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase subunit A2
Horse
NADH:ubiquinone oxidoreductase subunit A2
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43678-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (172)
1 – 10 of 172
NDUFV3
Tclin
Family:  Enzyme
Novelty:  0.15352039
p_int:  0.999715914
p_ni:  0.000284086
Score:  0.999
Data Source:  BioPlex,STRINGDB
PML
Tbio
Novelty:  0.00285474
p_int:  0.975937809
p_ni:  0.024062191
Score:  0.188
Data Source:  BioPlex,STRINGDB
NDUFB11
Tclin
Family:  Enzyme
Novelty:  0.0401232
p_int:  0.975377945
p_ni:  0.024622055
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFA7
Tclin
Family:  Enzyme
Novelty:  0.16417588
p_int:  0.931001429
p_ni:  0.068998571
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFS3
Tclin
Family:  Enzyme
Novelty:  0.01968313
p_int:  0.926711997
p_ni:  0.073288003
Score:  0.999
Data Source:  BioPlex,STRINGDB
NDUFS6
Tclin
Family:  Enzyme
Novelty:  0.07910252
p_int:  0.920306551
p_ni:  0.079693449
Score:  0.999
Data Source:  BioPlex,STRINGDB
WNT9B
Tbio
Novelty:  0.01146843
p_int:  0.901230285
p_ni:  0.098769705
p_wrong:  1e-8
Score:  0.416
Data Source:  BioPlex,STRINGDB
NDUFS8
Tclin
Family:  Enzyme
Novelty:  0.02408724
Score:  0.999
Data Source:  STRINGDB
NDUFS1
Tclin
Family:  Enzyme
Novelty:  0.0215624
Score:  0.999
Data Source:  STRINGDB
NDUFA9
Tclin
Family:  Enzyme
Novelty:  0.00637307
Score:  0.999
Data Source:  STRINGDB
Publication Statistics
PubMed Score  35.53

PubMed score by year
PubTator Score  84.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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