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Tclin
NDUFC1
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial

Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394223
  • ENSP00000377770
  • ENSG00000109390
  • ENST00000394228
  • ENSP00000377775
  • ENST00000503997
  • ENSP00000425882
  • ENST00000505036
  • ENSP00000421195
  • ENST00000539002
  • ENSP00000440133
  • ENST00000539387
  • ENSP00000439882
  • ENST00000544855
  • ENSP00000441126

Symbol
  • KFYI
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.94
virus perturbation
0.92
kinase perturbation
0.91
co-expressed gene
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.63   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.63   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (139)
NDUFB3
Tclin
Family:  Enzyme
Novelty:  0.13020753
Score:  0.999
Data Source:  STRINGDB
NDUFA6
Tclin
Family:  Enzyme
Novelty:  0.01236094
Score:  0.999
Data Source:  STRINGDB
NDUFB2
Tclin
Family:  Enzyme
Novelty:  0.05735054
Score:  0.999
Data Source:  STRINGDB
NDUFB1
Tclin
Family:  Enzyme
Novelty:  0.08981517
Score:  0.999
Data Source:  STRINGDB
NDUFAB1
Tclin
Novelty:  0.00190242
Score:  0.999
Data Source:  STRINGDB
NDUFB6
Tclin
Family:  Enzyme
Novelty:  0.075245
Score:  0.999
Data Source:  STRINGDB
NDUFA12
Tclin
Family:  Enzyme
Novelty:  0.04679316
Score:  0.999
Data Source:  STRINGDB
NDUFA2
Tclin
Family:  Enzyme
Novelty:  0.02698508
Score:  0.999
Data Source:  STRINGDB
NDUFB5
Tclin
Family:  Enzyme
Novelty:  0.0257403
Score:  0.999
Data Source:  STRINGDB
NDUFB4
Tclin
Family:  Enzyme
Novelty:  0.02123344
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
1
1
0
1.6
11.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
1.6
11.1
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1913627
66377
Rat
RGD:1586362
689938
Horse
NADH:ubiquinone oxidoreductase subunit C1
VGNC:50722
100629515
Cow
NADH:ubiquinone oxidoreductase subunit C1
VGNC:31968
282289
Opossum
NADH:ubiquinone oxidoreductase subunit C1
100019912
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
NADH:ubiquinone oxidoreductase subunit C1
Cow
NADH:ubiquinone oxidoreductase subunit C1
Opossum
NADH:ubiquinone oxidoreductase subunit C1
Publication Statistics
PubMed Score 1.63
PubMed score by year
PubTator Score 0.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title