NDUFC1
NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial
Protein Summary
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
- ENST00000394223
- ENSP00000377770
- ENSG00000109390
- ENST00000394228
- ENSP00000377775
- ENST00000503997
- ENSP00000425882
- ENST00000505036
- ENSP00000421195
- ENST00000539002
- ENSP00000440133
- ENST00000539387
- ENSP00000439882
- ENST00000544855
- ENSP00000441126
- KFYI
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
transcription factor perturbation | 0.94 | ||
virus perturbation | 0.92 | ||
kinase perturbation | 0.91 | ||
co-expressed gene | 0.82 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.99 (req: < 5)
Gene RIFs: 0 (req: <= 3)
Antibodies: 46 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2.99 (req: >= 5)
Gene RIFs: 0 (req: > 3)
Antibodies: 46 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1