Tclin NDUFB5 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

Protein Summary

Description

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• O43674
• Q561V6

Gene Name

• NDUFB5

Ensembl ID

• ENST00000259037
• ENSP00000259037
• ENSG00000136521
• ENST00000493866
• ENSP00000419656

Symbol

• SGDH
• CISGDH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
histone modification site profile	0.92
kinase perturbation	0.88
transcription factor binding site profile	0.72
cellular component	0.68

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Nadh Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 5, Mitochondrial

DTO Classes

Protein / Enzyme / Oxidoreductase / Nadh Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 5, Mitochondrial

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.7   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 123   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.7   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1