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Tclin
NDUFB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

Protein Classes
Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259037
  • ENSP00000259037
  • ENSG00000136521
  • ENST00000493866
  • ENSP00000419656

Symbol
  • SGDH
  • CISGDH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
histone modification site profile
0.92
kinase perturbation
0.88
transcription factor binding site profile
0.72
cellular component
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.5   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.5   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit B5
VGNC:7989
471008
Macaque
NADH:ubiquinone oxidoreductase subunit B5
708821
Mouse
MGI:1913296
66046
Rat
RGD:1305909
294964
Horse
NADH:ubiquinone oxidoreductase subunit B5
VGNC:20641
100058402
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit B5
Macaque
NADH:ubiquinone oxidoreductase subunit B5
Mouse
Rat
Horse
NADH:ubiquinone oxidoreductase subunit B5
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43674-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (185)
1 – 10 of 185
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.99999829
p_ni: 0.00000171
Score: 0.994
Data Source: BioPlex,STRINGDB
NDUFB11
Tclin
Family: Enzyme
Novelty: 0.0401232
p_int: 0.999997769
p_ni: 0.000002231
Score: 0.998
Data Source: BioPlex,STRINGDB
ECSIT
Tbio
Novelty: 0.04690184
p_int: 0.999976669
p_ni: 0.000023331
Score: 0.974
Data Source: BioPlex,STRINGDB
NDUFB6
Tclin
Family: Enzyme
Novelty: 0.075245
p_int: 0.999976463
p_ni: 0.000023467
p_wrong: 7e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB7
Tclin
Family: Enzyme
Novelty: 0.14580093
p_int: 0.999963598
p_ni: 0.000036174
p_wrong: 2.28e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
p_int: 0.999960137
p_ni: 0.000039863
Score: 0.998
Data Source: BioPlex,STRINGDB
ITM2A
Tbio
Novelty: 0.06374858
p_int: 0.999855473
p_ni: 0.00014437
p_wrong: 1.56e-7
Data Source: BioPlex
MT-ND4
Tclin
Family: Enzyme
Novelty: 0.00079935
p_int: 0.999807941
p_ni: 0.00019186
p_wrong: 1.99e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.999745235
p_ni: 0.000254712
p_wrong: 5.3e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
NCALD
Tbio
Novelty: 0.03665351
p_int: 0.999678201
p_ni: 0.000321798
p_wrong: 1e-9
Data Source: BioPlex
Publication Statistics
PubMed Score  38.50

PubMed score by year
PubTator Score  3.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer