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Tbio
ZNF207
BUB3-interacting and GLEBS motif-containing protein ZNF207

Protein Summary
Description
Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321233
  • ENSP00000322777
  • ENSG00000010244
  • ENST00000394670
  • ENSP00000378165
  • ENST00000394673
  • ENSP00000378168

Symbol
  • BUGZ
  • BuGZ
  • hBuGZ
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
0.97
virus perturbation
0.94
molecular function
0.86
transcription factor binding site profile
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.38   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 307   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.38   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 307   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
55.8
systolic blood pressure
1
1
1
42.3
chronotype measurement
1
1
1
17.8
1
1
0
1.1
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
55.8
systolic blood pressure
1
42.3
chronotype measurement
1
17.8
0
1.1
2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 207
VGNC:9803
101059401
Macaque
zinc finger protein 207
100689489
Mouse
MGI:1340045
22680
Rat
RGD:1308121
303763
Horse
zinc finger protein 207 [Source:HGNC Symbol;Acc:HGNC:12998]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
zinc finger protein 207
Macaque
zinc finger protein 207
Mouse
Rat
Horse
zinc finger protein 207 [Source:HGNC Symbol;Acc:HGNC:12998]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43670-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (25)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (65)
1 – 10 of 65
BUB3
Tbio
Novelty:  0.00714143
p_int:  0.999972817
p_ni:  0.000027183
p_wrong:  1e-9
Score:  0.979
Data Source:  BioPlex,STRINGDB
C17orf75
Tbio
Novelty:  0.08706784
Score:  0.933
Data Source:  STRINGDB
SF3A2
Tbio
Novelty:  0.03658692
Score:  0.85
Data Source:  STRINGDB
BUB1
Tchem
Family:  Kinase
Novelty:  0.00327514
Score:  0.837
Data Source:  STRINGDB
BUB1B
Tbio
Family:  Kinase
Novelty:  0.00239073
Score:  0.813
Data Source:  STRINGDB
HNRNPM
Tbio
Novelty:  0.0125566
Score:  0.792
Data Source:  STRINGDB
CCDC97
Tdark
Novelty:  2.36351796
Score:  0.748
Data Source:  STRINGDB
SF3B3
Tchem
Novelty:  0.02866311
Score:  0.711
Data Source:  STRINGDB
ZMAT2
Tbio
Novelty:  0.16771752
Score:  0.673
Data Source:  STRINGDB
MRPL3
Tbio
Novelty:  0.11814129
Score:  0.636
Data Source:  STRINGDB
Publication Statistics
PubMed Score  12.38

PubMed score by year
PubTator Score  6.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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