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Tbio
RGS10
Regulator of G-protein signaling 10

Protein Summary
Description
Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:8774883, PubMed:10608901, PubMed:9353196, PubMed:11443111, PubMed:18434541). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed:11443111). Activity on GNAZ is inhibited by palmitoylation of the G-protein (PubMed:9353196). Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369101
  • ENSP00000358097
  • ENSG00000148908
  • ENST00000369103
  • ENSP00000358099
  • ENST00000392865
  • ENSP00000376605
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
transcription factor perturbation
0.91
PubMedID
0.88
transcription factor
0.88
transcription factor binding site profile
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.12   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.12   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
depressive symptom measurement
1
1
1
3.2
stressful life event measurement
1
1
1
3.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
depressive symptom measurement
1
3.2
stressful life event measurement
1
3.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
regulator of G protein signaling 10
VGNC:12458
741334
Macaque
regulator of G protein signaling 10
703125
Mouse
MGI:1915115
67865
Rat
RGD:3562
54290
Dog
regulator of G protein signaling 10
VGNC:45520
477840
Species
Name
OMA
EggNOG
Inparanoid
Chimp
regulator of G protein signaling 10
Macaque
regulator of G protein signaling 10
Mouse
Rat
Dog
regulator of G protein signaling 10
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43665-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (39)
1 – 10 of 39
GNAI3
Tbio
Novelty: 0.03484857
Score: 0.997
Data Source: STRINGDB
GNAI1
Tbio
Novelty: 0.0488971
Score: 0.972
Data Source: STRINGDB
GNAI2
Tbio
Novelty: 0.03014729
Score: 0.947
Data Source: STRINGDB
GNAT3
Tbio
Novelty: 0.00702357
Score: 0.941
Data Source: STRINGDB
GNG7
Tbio
Novelty: 0.08478455
Score: 0.801
Data Source: STRINGDB
GNG5
Tbio
Novelty: 0.1525101
Score: 0.8
Data Source: STRINGDB
GNG8
Tdark
Novelty: 0.00590503
Score: 0.757
Data Source: STRINGDB
GNG12
Tbio
Novelty: 0.12611933
Score: 0.754
Data Source: STRINGDB
GNG11
Tbio
Novelty: 0.10721743
Score: 0.751
Data Source: STRINGDB
GNG3
Tbio
Novelty: 0.16941216
Score: 0.748
Data Source: STRINGDB
Publication Statistics
PubMed Score  41.12

PubMed score by year
PubTator Score  25.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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