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Tbio
PRC1
Protein regulator of cytokinesis 1

Protein Summary
Description
Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). This gene encodes a protein that is involved in cytokinesis. The protein is present at high levels during the S and G2/M phases of mitosis but its levels drop dramatically when the cell exits mitosis and enters the G1 phase. It is located in the nucleus during interphase, becomes associated with mitotic spindles in a highly dynamic manner during mitosis, and localizes to the cell mid-body during cytokinesis. This protein has been shown to be a subs ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361188
  • ENSP00000354679
  • ENSG00000198901
  • ENST00000394249
  • ENSP00000377793
  • ENST00000442656
  • ENSP00000409549

Symbol
  • ASE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
gene perturbation
0.89
histone modification site profile
0.87
ligand (protein) perturbation
0.83
cellular component
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.88   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 226   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.88   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 226   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (271)
LTBR
Tbio
Novelty:  0.003823
p_int:  0.999999962
p_ni:  3.5e-8
p_wrong:  3e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
THRSP
Tbio
Novelty:  0.00938864
p_int:  0.9996554
p_ni:  0.000011307
p_wrong:  0.000333293
Data Source:  BioPlex
IFI30
Tbio
Family:  Enzyme
Novelty:  0.00939681
p_int:  0.998210229
p_ni:  0.000043397
p_wrong:  0.001746374
Score:  0.187
Data Source:  BioPlex,STRINGDB
ACSM1
Tbio
Family:  Enzyme
Novelty:  0.01901085
p_int:  0.997540589
p_ni:  0.002396045
p_wrong:  0.000063366
Score:  0.379
Data Source:  BioPlex,STRINGDB
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
Score:  0.998
Data Source:  STRINGDB
KIF20A
Tchem
Novelty:  0.01640924
Score:  0.994
Data Source:  STRINGDB
KIF11
Tchem
Novelty:  0.00170673
Score:  0.992
Data Source:  STRINGDB
KIF14
Tbio
Novelty:  0.02313641
Score:  0.991
Data Source:  Reactome,STRINGDB
KIF4A
Tbio
Novelty:  0.00888393
Score:  0.988
Data Source:  STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
Score:  0.988
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases activate CIT
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases activate CIT
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
6
7
99.5
7
6
4
1.1
96.2
9
5
4
1.1
95.1
mean platelet volume
3
2
3
93.3
3
3
0
1.1
91.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
7
99.5
4
1.1
96.2
4
1.1
95.1
mean platelet volume
3
93.3
0
1.1
91.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein regulator of cytokinesis 1
VGNC:1895
453656
Macaque
protein regulator of cytokinesis 1
710182
Mouse
MGI:1858961
233406
Rat
RGD:1311754
308761
Dog
protein regulator of cytokinesis 1
VGNC:44941
488742
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein regulator of cytokinesis 1
Macaque
protein regulator of cytokinesis 1
Mouse
Rat
Dog
protein regulator of cytokinesis 1
Publication Statistics
PubMed Score 16.88
PubMed score by year
PubTator Score 170.01
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title