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Tbio
NCK2
Cytoplasmic protein NCK2

Protein Summary
Description
Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233154
  • ENSP00000233154
  • ENSG00000071051
  • ENST00000393349
  • ENSP00000377018

Symbol
  • GRB4
  • GRB4
  • NCKbeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
disease perturbation
0.93
hub protein
0.85
pathway
0.72
PubMedID
0.69


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.37   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 311   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.37   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 311   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
77.9
1
1
0
13.9
68.4
eosinophil count
1
1
1
65
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
77.9
0
13.9
68.4
eosinophil count
1
65
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NCK adaptor protein 2
VGNC:305
459472
Macaque
NCK adaptor protein 2
713287
Mouse
MGI:1306821
17974
Rat
RGD:1305965
316369
Dog
NCK adaptor protein 2
VGNC:43652
481319
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NCK adaptor protein 2
Macaque
NCK adaptor protein 2
Mouse
Rat
Dog
NCK adaptor protein 2
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O43639-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (37)
Activation of RAC1 (R-HSA-428540)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of RAC1
Reactome
Axon guidance
Reactome
Cell-Cell communication
Reactome
Developmental Biology
Reactome
Downstream signal transduction
Name
Explore in Pharos
Explore in Source
Activation of RAC1
Axon guidance
Cell-Cell communication
Developmental Biology
Downstream signal transduction
Gene Ontology Terms (33)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (217)
1 – 10 of 217
WASL
Tbio
Novelty: 0.0029314
p_int: 1
Score: 0.987
Data Source: BioPlex,Reactome,STRINGDB
WIPF1
Tbio
Novelty: 0.00427982
p_int: 0.999999997
p_ni: 1e-9
p_wrong: 2e-9
Score: 0.705
Data Source: BioPlex,STRINGDB
CASKIN2
Tdark
Novelty: 0.43801968
p_int: 0.999999993
p_ni: 1e-9
p_wrong: 7e-9
Score: 0.591
Data Source: BioPlex,STRINGDB
WIPF2
Tbio
Novelty: 0.11973409
p_int: 0.999999992
p_ni: 8e-9
Score: 0.798
Data Source: BioPlex,STRINGDB
RAPH1
Tbio
Novelty: 0.02440794
p_int: 0.999999986
p_ni: 1.2e-8
p_wrong: 2e-9
Score: 0.602
Data Source: BioPlex,STRINGDB
PIK3AP1
Tbio
Family: Enzyme
Novelty: 0.11565645
p_int: 0.999999984
p_ni: 3e-9
p_wrong: 1.3e-8
Score: 0.724
Data Source: BioPlex,STRINGDB
PAK1
Tchem
Family: Kinase
Novelty: 0.00411227
p_int: 0.999999982
p_ni: 1.8e-8
Score: 0.973
Data Source: BioPlex,Reactome,STRINGDB
SH3PXD2B
Tbio
Novelty: 0.04207866
p_int: 0.999999978
p_ni: 1.1e-8
p_wrong: 1.1e-8
Score: 0.305
Data Source: BioPlex,STRINGDB
WIPF3
Tdark
Novelty: 0.0257625
p_int: 0.999999973
p_ni: 2.5e-8
p_wrong: 1e-9
Score: 0.621
Data Source: BioPlex,STRINGDB
TNIK
Tchem
Family: Kinase
Novelty: 0.02681864
p_int: 0.999999966
p_ni: 3.2e-8
p_wrong: 2e-9
Score: 0.505
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  40.37

PubMed score by year
PubTator Score  31.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer