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Tbio
CHMP2A
Charged multivesicular body protein 2a

Protein Summary
Description
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis (PubMed:21310966). Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase (PubMed:26040712). ESCRT-III pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312547
  • ENSP00000310440
  • ENSG00000130724
  • ENST00000600118
  • ENSP00000469240
  • ENST00000601220
  • ENSP00000472680

Symbol
  • BC2
  • CHMP2
  • BC2
  • BC-2
  • VPS2
  • CHMP2
  • VPS2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
disease perturbation
0.95
kinase perturbation
0.93
biological process
0.8
transcription factor binding site profile
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 600.55   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 600.55   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (17)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Budding and maturation of HIV virion
Reactome
Cellular responses to external stimuli
Reactome
Disease
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Name
Explore in Pharos
Explore in Source
Autophagy
Budding and maturation of HIV virion
Cellular responses to external stimuli
Disease
Endosomal Sorting Complex Required For Transport (ESCRT)
Gene Ontology Terms (37)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (115)
1 – 10 of 115
TRIM35
Tbio
Novelty: 0.03280419
p_int: 0.99999577
p_ni: 0.000004174
p_wrong: 5.6e-8
Score: 0.201
Data Source: BioPlex,STRINGDB
VTA1
Tbio
Novelty: 0.01697854
p_int: 0.999863822
p_ni: 0.000136178
Score: 0.997
Data Source: BioPlex,STRINGDB
DECR1
Tbio
Family: Enzyme
Novelty: 0.02699187
p_int: 0.962858147
p_ni: 0.037141853
Score: 0.209
Data Source: BioPlex,STRINGDB
MAX
Tbio
Family: TF
Novelty: 0.00799068
p_int: 0.955319245
p_ni: 0.02551803
p_wrong: 0.019162725
Data Source: BioPlex
CHMP5
Tbio
Novelty: 0.03378716
p_int: 0.953081705
p_ni: 0.046918295
Score: 0.998
Data Source: BioPlex,STRINGDB
SIX2
Tbio
Family: TF
Novelty: 0.01046481
p_int: 0.910897088
p_ni: 0.089101811
p_wrong: 0.0000011
Score: 0.185
Data Source: BioPlex,STRINGDB
DAXX
Tbio
Novelty: 0.00348585
p_int: 0.907849711
p_ni: 0.04708827
p_wrong: 0.045062018
Data Source: BioPlex
STAMBP
Tbio
Novelty: 0.01543821
p_int: 0.890692525
p_ni: 0.109302681
p_wrong: 0.000004794
Score: 0.839
Data Source: BioPlex,STRINGDB
SPAST
Tbio
Novelty: 0.00303236
p_int: 0.886767684
p_ni: 0.086734805
p_wrong: 0.026497511
Score: 0.87
Data Source: BioPlex,STRINGDB
SNAP23
Tbio
Novelty: 0.0065371
p_int: 0.864122703
p_ni: 0.135877207
p_wrong: 9e-8
Score: 0.226
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  600.55

PubMed score by year
PubTator Score  140.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer