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Tbio
TRAPPC3
Trafficking protein particle complex subunit 3

Protein Summary
Description
May play a role in vesicular transport from endoplasmic reticulum to Golgi. This gene encodes a component of the trafficking protein particle complex, which tethers transport vesicles to the cis-Golgi membrane. The encoded protein participates in the regulation of transport from the endoplasmic reticulum to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373162
  • ENSP00000362256
  • ENSG00000054116
  • ENST00000373163
  • ENSP00000362257
  • ENST00000373166
  • ENSP00000362261
  • ENST00000617904
  • ENSP00000480648

Symbol
  • BET3
  • BET3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
co-expressed gene
0.99
transcription factor binding site profile
0.96
kinase perturbation
0.95
interacting protein
0.94


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.05   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.05   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (115)
TRAPPC5
Tdark
Novelty:  0.22558077
p_int:  0.999999185
p_ni:  8.14e-7
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
TRAPPC1
Tbio
Novelty:  0.09781468
p_int:  0.99998851
p_ni:  0.00001149
Score:  0.999
Data Source:  BioPlex,STRINGDB
TRAPPC2
Tbio
Novelty:  0.02016231
p_int:  0.999982263
p_ni:  0.000017737
Score:  0.999
Data Source:  BioPlex,STRINGDB
TRAPPC12
Tbio
Novelty:  0.09847363
p_int:  0.997958493
p_ni:  0.002041507
Score:  0.993
Data Source:  BioPlex,STRINGDB
STMN4
Tbio
Novelty:  0.00422625
p_int:  0.995485056
p_ni:  0.004514944
Score:  0.81
Data Source:  BioPlex,STRINGDB
TBC1D14
Tbio
Novelty:  0.25089884
p_int:  0.993655677
p_ni:  0.006344323
Score:  0.824
Data Source:  BioPlex,STRINGDB
BCL2L14
Tbio
Novelty:  0.03980069
p_int:  0.993653018
p_ni:  0.006346981
p_wrong:  1e-9
Score:  0.849
Data Source:  BioPlex,STRINGDB
RAB43
Tbio
Family:  Enzyme
Novelty:  0.07527576
p_int:  0.987945017
p_ni:  0.012054944
p_wrong:  3.9e-8
Score:  0.516
Data Source:  BioPlex,STRINGDB
KANK4
Tdark
Novelty:  0.22871735
p_int:  0.970029287
p_ni:  0.029970713
Score:  0.811
Data Source:  BioPlex,STRINGDB
GLB1
Tchem
Family:  Enzyme
Novelty:  0.00241713
p_int:  0.966443845
p_ni:  0.033556155
Score:  0.735
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPII-mediated vesicle transport
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPII-mediated vesicle transport
ER to Golgi Anterograde Transport
Membrane Trafficking
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
3
3
4
75.5
reticulocyte count
2
1
2
63.7
reticulocyte measurement
2
1
2
62.1
corneal topography
1
1
1
48.5
central corneal thickness
2
1
0
2.1
48.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
75.5
reticulocyte count
2
63.7
reticulocyte measurement
2
62.1
corneal topography
1
48.5
central corneal thickness
0
2.1
48.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trafficking protein particle complex 3
VGNC:1699
456506
Macaque
trafficking protein particle complex 3
713705
Mouse
MGI:1351486
27096
Rat
RGD:1309135
362599
Dog
trafficking protein particle complex 3
VGNC:47781
482477
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trafficking protein particle complex 3
Macaque
trafficking protein particle complex 3
Mouse
Rat
Dog
trafficking protein particle complex 3
Publication Statistics
PubMed Score 29.05
PubMed score by year
PubTator Score 103.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title