Tbio TIMM44 Mitochondrial import inner membrane translocase subunit TIM44

Protein Summary

Description

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Recruits mitochondrial HSP70 to drive protein translocation into the matrix using ATP as an energy source. This gene encodes a peripheral membrane protein associated with the mitochondrial inner membrane translocase, which functions in the import of proteins across the mitochondrial inner membrane and into the mitochondrial matrix. The encoded protein mediates binding of mitochondrial heat shock protein 70 to the translocase of inner mitochondrial membrane 23 (TIM23) complex. Expression of this gene is upregulated in kidney in a mouse model of diabetes. A mutation in this gene is associated with familial oncocytic thyroid carcinoma. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• O43615
• A8K0R9
• D6W664
• Q8N193

Gene Name

• TIMM44

Ensembl ID

• ENST00000270538
• ENSP00000270538
• ENSG00000104980

Symbol

• MIMT44
• TIM44
• TIM44

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
disease perturbation	0.95
kinase perturbation	0.93
histone modification site profile	0.88
transcription factor binding site profile	0.88

Protein Classes

PANTHER Classes

Protein / Transporter / Mitochondrial Carrier Protein / Mitochondrial Import Inner Membrane Translocase Subunit Tim44

Protein / Transfer/carrier Protein / Mitochondrial Import Inner Membrane Translocase Subunit Tim44

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.15   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 53   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 49.15   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 53   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0