Protein Classes
Protein Summary
Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369). The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]
- ENST00000370862
- ENSP00000359899
- ENSG00000137252
- ENST00000615358
- ENSP00000477548
- OX2R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.98 | ||
gene perturbation | 0.67 | ||
molecular function | 0.6 | ||
protein domain | 0.58 | ||
ligand (chemical) | 0.54 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 84.87 (req: < 5)
Gene RIFs: 41 (req: <= 3)
Antibodies: 346 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 84.87 (req: >= 5)
Gene RIFs: 41 (req: > 3)
Antibodies: 346 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1280
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
Active Ligands (1280)
1 – 10 of 1280
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
chronotype measurement | 4 | 4 | 4 | 1.1 | 99.2 | ||||
circadian rhythm | 2 | 2 | 1 | 1.1 | 69.7 | ||||
red blood cell density measurement | 1 | 1 | 1 | 66.2 | |||||
hematocrit | 1 | 1 | 1 | 53.3 | |||||
daytime rest measurement | 1 | 1 | 0 | 1.1 | 51 | ||||
Items per page:
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
chronotype measurement | 4 | 1.1 | 99.2 | ||||
circadian rhythm | 1 | 1.1 | 69.7 | ||||
red blood cell density measurement | 1 | 66.2 | |||||
hematocrit | 1 | 53.3 | |||||
daytime rest measurement | 0 | 1.1 | 51 | ||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | hypocretin receptor 2 | VGNC:7185 | 462786 | |||||
Macaque | hypocretin receptor 2 | 711662 | ||||||
Mouse | MGI:2680765 | 387285 | ||||||
Rat | RGD:2788 | 25605 | ||||||
Dog | hypocretin receptor 2 | VGNC:41624 | 399545 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | hypocretin receptor 2 | |||||
Macaque | hypocretin receptor 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | hypocretin receptor 2 | |||||
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (13)
Reactome (8)
KEGG (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Orexin and neuropeptides FF and QRFP bind to their respective receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Orexin and neuropeptides FF and QRFP bind to their respective receptors | ||||
Gene Ontology Terms (14)
Functions (4)
Components (2)
Processes (8)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (175)
1 – 10 of 175
HCRT
Novelty: 0.00034048
Score: 0.995
Data Source: Reactome,STRINGDB
NPS
Novelty: 0.00692108
Score: 0.964
Data Source: STRINGDB
NTS
Novelty: 0.00033201
Score: 0.94
Data Source: STRINGDB
NMB
Novelty: 0.00729571
Score: 0.925
Data Source: STRINGDB
NPFF
Novelty: 0.00489546
Score: 0.924
Data Source: STRINGDB
GNB3
Novelty: 0.0037117
Score: 0.921
Data Source: STRINGDB
OXT
Novelty: 0.00005116
Score: 0.921
Data Source: STRINGDB
CCK
Novelty: 0.00012268
Score: 0.92
Data Source: STRINGDB
GRM1
Family: GPCR
Novelty: 0.00099764
Score: 0.92
Data Source: STRINGDB
AVP
Novelty: 0.00016475
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score 84.87
PubMed score by year
PubTator Score 83.44
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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