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Tclin
HCRTR2
Orexin receptor type 2

Protein Summary
Description
Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369). The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370862
  • ENSP00000359899
  • ENSG00000137252
  • ENST00000615358
  • ENSP00000477548

Symbol
  • OX2R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.98
gene perturbation
0.67
molecular function
0.6
protein domain
0.58
ligand (chemical)
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.87   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 346   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.87   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 346   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1280
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
4
4
4
1.1
99.2
circadian rhythm
2
2
1
1.1
69.7
red blood cell density measurement
1
1
1
66.2
hematocrit
1
1
1
53.3
daytime rest measurement
1
1
0
1.1
51
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
4
1.1
99.2
circadian rhythm
1
1.1
69.7
red blood cell density measurement
1
66.2
hematocrit
1
53.3
daytime rest measurement
0
1.1
51
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hypocretin receptor 2
VGNC:7185
462786
Macaque
hypocretin receptor 2
711662
Mouse
MGI:2680765
387285
Rat
RGD:2788
25605
Dog
hypocretin receptor 2
VGNC:41624
399545
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hypocretin receptor 2
Macaque
hypocretin receptor 2
Mouse
Rat
Dog
hypocretin receptor 2
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Orexin and neuropeptides FF and QRFP bind to their respective receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Orexin and neuropeptides FF and QRFP bind to their respective receptors
Protein-Protein Interactions (175)
1 – 10 of 175
HCRT
Tbio
Novelty: 0.00034048
Score: 0.995
Data Source: Reactome,STRINGDB
NPS
Tbio
Novelty: 0.00692108
Score: 0.964
Data Source: STRINGDB
NTS
Tbio
Novelty: 0.00033201
Score: 0.94
Data Source: STRINGDB
NMB
Tbio
Novelty: 0.00729571
Score: 0.925
Data Source: STRINGDB
NPFF
Tbio
Novelty: 0.00489546
Score: 0.924
Data Source: STRINGDB
GNB3
Tbio
Novelty: 0.0037117
Score: 0.921
Data Source: STRINGDB
OXT
Tbio
Novelty: 0.00005116
Score: 0.921
Data Source: STRINGDB
CCK
Tbio
Novelty: 0.00012268
Score: 0.92
Data Source: STRINGDB
GRM1
Tchem
Family: GPCR
Novelty: 0.00099764
Score: 0.92
Data Source: STRINGDB
AVP
Tbio
Novelty: 0.00016475
Score: 0.918
Data Source: STRINGDB
Publication Statistics
PubMed Score  84.87

PubMed score by year
PubTator Score  83.44

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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