Protein Summary
Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369). The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]
- ENST00000370862
- ENSP00000359899
- ENSG00000137252
- ENST00000615358
- ENSP00000477548
- OX2R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
co-expressed gene | 0.98 | ||
gene perturbation | 0.67 | ||
molecular function | 0.6 | ||
protein domain | 0.58 | ||
ligand (chemical) | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 99.62 (req: < 5)
Gene RIFs: 41 (req: <= 3)
Antibodies: 346 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 99.62 (req: >= 5)
Gene RIFs: 41 (req: > 3)
Antibodies: 346 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1475
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (1475)
Protein-Protein Interactions (175)
Nearest Tclin Targets
Pathways (13)
Reactome (8)
KEGG (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Orexin and neuropeptides FF and QRFP bind to their respective receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Orexin and neuropeptides FF and QRFP bind to their respective receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (4)
Components (2)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
chronotype measurement | 4 | 6 | 5 | 1.1 | 98.6 | ||||
daytime rest measurement | 2 | 2 | 1 | 1.1 | 97.4 | ||||
blood urea nitrogen measurement | 3 | 2 | 3 | 92 | |||||
circadian rhythm | 2 | 2 | 1 | 1.1 | 78.8 | ||||
uric acid measurement | 1 | 1 | 1 | 78.6 | |||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
chronotype measurement | 5 | 1.1 | 98.6 | ||||
daytime rest measurement | 1 | 1.1 | 97.4 | ||||
blood urea nitrogen measurement | 3 | 92 | |||||
circadian rhythm | 1 | 1.1 | 78.8 | ||||
uric acid measurement | 1 | 78.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | hypocretin receptor 2 | VGNC:7185 | 462786 | |||||
Macaque | hypocretin receptor 2 | 711662 | ||||||
Mouse | MGI:2680765 | 387285 | ||||||
Rat | RGD:2788 | 25605 | ||||||
Dog | hypocretin receptor 2 | VGNC:41624 | 399545 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | hypocretin receptor 2 | |||||
Macaque | hypocretin receptor 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | hypocretin receptor 2 | |||||
Publication Statistics
PubMed Score 99.62
PubMed score by year
PubTator Score 83.44
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (70)
GeneRif Annotations (41)
Items per page:
0 of 0
PMID | Year | Title |
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