HCRTR1
Orexin receptor type 1
Protein Summary
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369). The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]
- ENST00000373706
- ENSP00000362810
- ENSG00000121764
- ENST00000403528
- ENSP00000384387
- OX1R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.7 | ||
cell line | 0.65 | ||
histone modification site profile | 0.65 | ||
molecular function | 0.6 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 361.28 (req: < 5)
Gene RIFs: 65 (req: <= 3)
Antibodies: 383 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 361.28 (req: >= 5)
Gene RIFs: 65 (req: > 3)
Antibodies: 383 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1225
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2