Protein Classes
Protein Summary
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369). The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]
- ENST00000373706
- ENSP00000362810
- ENSG00000121764
- ENST00000403528
- ENSP00000384387
- OX1R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.7 | ||
cell line | 0.65 | ||
histone modification site profile | 0.65 | ||
molecular function | 0.6 | ||
protein domain | 0.58 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 205.18 (req: < 5)
Gene RIFs: 51 (req: <= 3)
Antibodies: 383 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 205.18 (req: >= 5)
Gene RIFs: 51 (req: > 3)
Antibodies: 383 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1026
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Approved Drugs (2)
1 – 2 of 2
Active Ligands (1026)
1 – 10 of 1026
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (13)
Reactome (8)
KEGG (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Orexin and neuropeptides FF and QRFP bind to their respective receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Orexin and neuropeptides FF and QRFP bind to their respective receptors | ||||
Gene Ontology Terms (11)
Functions (3)
Components (2)
Processes (6)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (191)
1 – 10 of 191
HCRT
Novelty: 0.00044523
Score: 0.994
Data Source: Reactome,STRINGDB
NPS
Novelty: 0.00011983
Score: 0.972
Data Source: STRINGDB
NTS
Novelty: 0.00035891
Score: 0.949
Data Source: STRINGDB
NPFF
Novelty: 0.00350925
Score: 0.943
Data Source: STRINGDB
OXT
Novelty: 0.00006195
Score: 0.928
Data Source: STRINGDB
NMB
Novelty: 0.00867711
Score: 0.928
Data Source: STRINGDB
CCK
Novelty: 0.00013779
Score: 0.927
Data Source: STRINGDB
PMCH
Novelty: 0.005002
Score: 0.925
Data Source: STRINGDB
TRH
Novelty: 0.00054889
Score: 0.923
Data Source: STRINGDB
AVP
Novelty: 0.0001163
Score: 0.921
Data Source: STRINGDB
Publication Statistics
PubMed Score 205.18
PubMed score by year
PubTator Score 90.79
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Sequence
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLA
1-70
VWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFI
70-140
ALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDL
140-210
YPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRA
210-280
RAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYAN
280-350
SAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
350-420
TTVLP
420-425
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
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