Protein Summary
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369). The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]
- ENST00000373706
- ENSP00000362810
- ENSG00000121764
- ENST00000403528
- ENSP00000384387
- OX1R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.7 | ||
cell line | 0.65 | ||
histone modification site profile | 0.65 | ||
molecular function | 0.6 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 361.28 (req: < 5)
Gene RIFs: 51 (req: <= 3)
Antibodies: 383 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 361.28 (req: >= 5)
Gene RIFs: 51 (req: > 3)
Antibodies: 383 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1225
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (1225)
Protein-Protein Interactions (191)
Nearest Tclin Targets
Pathways (13)
Reactome (8)
KEGG (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | GPCR ligand binding | ||||
Reactome | Orexin and neuropeptides FF and QRFP bind to their respective receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
GPCR ligand binding | ||||
Orexin and neuropeptides FF and QRFP bind to their respective receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (11)
Functions (3)
Components (2)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
intelligence | 5 | 15 | 7 | 5.8 | 93.4 | ||||
self reported educational attainment | 2 | 2 | 1 | 6.1 | 77.9 | ||||
cognitive function measurement | 3 | 2 | 3 | 76.3 | |||||
body mass index | 3 | 3 | 3 | 60.6 | |||||
smoking status measurement | 2 | 1 | 2 | 59.5 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
intelligence | 7 | 5.8 | 93.4 | ||||
self reported educational attainment | 1 | 6.1 | 77.9 | ||||
cognitive function measurement | 3 | 76.3 | |||||
body mass index | 3 | 60.6 | |||||
smoking status measurement | 2 | 59.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | hypocretin receptor 1 | VGNC:8049 | 469261 | |||||
Macaque | hypocretin receptor 1 | 705914 | ||||||
Mouse | MGI:2385650 | 230777 | ||||||
Rat | RGD:2787 | 25593 | ||||||
Dog | hypocretin receptor 1 | VGNC:41623 | 100855896 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | hypocretin receptor 1 | |||||
Macaque | hypocretin receptor 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | hypocretin receptor 1 | |||||
Publication Statistics
PubMed Score 361.28
PubMed score by year
PubTator Score 90.79
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (67)
GeneRif Annotations (51)
Items per page:
0 of 0
PMID | Year | Title |
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