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Tclin
HCRTR1
Orexin receptor type 1

Protein Summary
Description
Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide (PubMed:9491897, PubMed:26950369). Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding (PubMed:9491897, PubMed:26950369). The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373706
  • ENSP00000362810
  • ENSG00000121764
  • ENST00000403528
  • ENSP00000384387

Symbol
  • OX1R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.7
cell line
0.65
histone modification site profile
0.65
molecular function
0.6
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 361.28   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 383   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 361.28   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 383   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1225
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (191)
HCRT
Tbio
Novelty:  0.00034048
Score:  0.994
Data Source:  Reactome,STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.972
Data Source:  STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.949
Data Source:  STRINGDB
NPFF
Tbio
Novelty:  0.00489546
Score:  0.943
Data Source:  STRINGDB
OXT
Tbio
Novelty:  0.00005116
Score:  0.928
Data Source:  STRINGDB
NMB
Tbio
Novelty:  0.00729571
Score:  0.928
Data Source:  STRINGDB
CCK
Tbio
Novelty:  0.00012268
Score:  0.927
Data Source:  STRINGDB
PMCH
Tbio
Novelty:  0.00600873
Score:  0.925
Data Source:  STRINGDB
TRH
Tbio
Novelty:  0.00052673
Score:  0.923
Data Source:  STRINGDB
AVP
Tbio
Novelty:  0.00016475
Score:  0.921
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Orexin and neuropeptides FF and QRFP bind to their respective receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Orexin and neuropeptides FF and QRFP bind to their respective receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
5
15
7
5.8
93.4
self reported educational attainment
2
2
1
6.1
77.9
cognitive function measurement
3
2
3
76.3
body mass index
3
3
3
60.6
smoking status measurement
2
1
2
59.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
7
5.8
93.4
self reported educational attainment
1
6.1
77.9
cognitive function measurement
3
76.3
body mass index
3
60.6
smoking status measurement
2
59.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hypocretin receptor 1
VGNC:8049
469261
Macaque
hypocretin receptor 1
705914
Mouse
MGI:2385650
230777
Rat
RGD:2787
25593
Dog
hypocretin receptor 1
VGNC:41623
100855896
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hypocretin receptor 1
Macaque
hypocretin receptor 1
Mouse
Rat
Dog
hypocretin receptor 1
Publication Statistics
PubMed Score 361.28
PubMed score by year
PubTator Score 90.79
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title