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Tbio
HCRT
Orexin

Protein Summary
Description
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity. This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000293330
  • ENSP00000293330
  • ENSG00000161610

Symbol
  • OX
  • PPORX
  • PPOX
  • OX
  • PPOX
  • NRCLP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue
0.87
biological term
0.81
cellular component
0.76
biological process
0.74
cell type or tissue
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3277.11   (req: < 5)
Gene RIFs: 101   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3277.11   (req: >= 5)
Gene RIFs: 101   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (266)
HCRTR2
Tclin
Family:  GPCR
Novelty:  0.00960861
Score:  0.995
Data Source:  Reactome,STRINGDB
HCRTR1
Tclin
Family:  GPCR
Novelty:  0.00318731
Score:  0.994
Data Source:  Reactome,STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.986
Data Source:  STRINGDB
PMCH
Tbio
Novelty:  0.00600873
Score:  0.976
Data Source:  STRINGDB
OXT
Tbio
Novelty:  0.00005116
Score:  0.968
Data Source:  STRINGDB
TRH
Tbio
Novelty:  0.00052673
Score:  0.967
Data Source:  STRINGDB
CCK
Tbio
Novelty:  0.00012268
Score:  0.966
Data Source:  STRINGDB
GNRH1
Tbio
Novelty:  0.00020807
Score:  0.965
Data Source:  STRINGDB
NPFFR2
Tchem
Family:  GPCR
Novelty:  0.01703886
Score:  0.965
Data Source:  STRINGDB
NTS
Tbio
Novelty:  0.00033201
Score:  0.963
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Orexin and neuropeptides FF and QRFP bind to their respective receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Orexin and neuropeptides FF and QRFP bind to their respective receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
2
2
77.8
3
2
3
65.7
mean reticulocyte volume
1
1
1
65.6
Thyroid preparation use measurement
1
1
1
61.4
waist-hip ratio
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
77.8
3
65.7
mean reticulocyte volume
1
65.6
Thyroid preparation use measurement
1
61.4
waist-hip ratio
1
57.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
hypocretin neuropeptide precursor
VGNC:12260
742546
Macaque
hypocretin neuropeptide precursor
709564
Mouse
MGI:1202306
15171
Rat
RGD:2786
25723
Dog
hypocretin neuropeptide precursor
VGNC:41622
607641
Species
Name
OMA
EggNOG
Inparanoid
Chimp
hypocretin neuropeptide precursor
Macaque
hypocretin neuropeptide precursor
Mouse
Rat
Dog
hypocretin neuropeptide precursor
Publication Statistics
PubMed Score 3277.11
PubMed score by year
PubTator Score 810.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title